ArticleBMC public health2021
Obesity and overall mortality: findings from the Jackson Heart Study.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Complementary and Alternative Therapies for Weight Loss: A Narrative Review.Journal of evidence-based integrative medicinePooled it
- Combination of triglyceride-glucose index and waist-to-height ratio as a predictor of all-cause and cardiovascular mortality in adults with diabetes or prediabetes: a nationwide prospective cohort study.Cardiovascular diagnosis and therapy · 2025Article
- Revisiting obesity thresholds for cardiovascular disease and mortality risk in Chinese adults: Age- and gender-specific insights.Cell reports. Medicine · 2025Article
- Unsupervised clustering of biochemical markers reveals health profiles associated with function and survival in active aging.Scientific reports · 2025Article
- Metabolic dysfunction-associated steatotic liver disease, metabolic alcohol-related liver disease, and incident dementia: a nationwide cohort study : MASLD, MetALD, and dementia risk.BMC gastroenterology · 2025Article
- Association between Body Roundness Index and diastolic function in middle-aged and older adults: a cross-sectional study.Frontiers in cardiovascular medicine · 2025Article
- The Impact of the Endocrine and Immunological Function of Adipose Tissue on Reproduction in Women with Obesity.International journal of molecular sciences · 2024Review
- Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease.Cardiovascular diabetology · 2024Article
- Influence of Obesity on Short-Term Surgical Outcomes in HFrEF Patients Undergoing CABG: A Retrospective Multicenter Study.Biomedicines · 2024Article
- Associations of body roundness index with cardiovascular and all-cause mortality: NHANES 2001-2018.Journal of human hypertension · 2024Article
- The impact of obesity on different glucose tolerance status with incident cardiovascular disease and mortality events over 15 years of follow-up: a pooled cohort analysis.Diabetology & metabolic syndrome · 2024Article
- Association between diverse obesity indicators and sleep quality in elderly Chinese people: a National Study.Frontiers in nutrition · 2024Article
- Anti-Obesity Effects of Marine Macroalgae ExtractMarine drugs · 2023Article
- Cross-sectional and longitudinal analyses of variations of anthropometric measures of obesity with age in the Jackson Heart Study.BMJ open · 2023Article
- Contributors to Early Mortality in African Americans, the Jackson Heart Study.Ethnicity & disease · 2023Article
- Sex Differences in the Relationship between Abdominal Obesity and Cardiovascular Death in Elderly Patients with Permanent Pacemakers Implantation: A Retrospective Cohort Study.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System.International journal of environmental research and public health · 2022Review
- Sex Differences in Adiposity and Cardiovascular Diseases.International journal of molecular sciences · 2022Review
- Influencing factors of obesity in community patients with deficit schizophrenia: a cross-sectional study.European journal of medical research · 2022Article
- Association between Three Waist Circumference-Related Obesity Metrics and Estimated Glomerular Filtration Rates.Journal of clinical medicine · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOverall mortality has been reported to be lower among individuals classified as overweight/obese when compared with their normal weight counterparts ("obesity paradox") when obesity classification is based on the body mass index (BMI). One possible reason for this apparent paradox is that BMI is not a reliable measure of obesity-related risk as it does not differentiate fat mass from lean muscle mass or fat mass phenotypes. Waist circumference (WC), as a measure of central adiposity, may be a better indicator of obesity-related risk. We examined the association of overall mortality with BMI and with WC measures, including WC, waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR).
methodsData from 3976 African American participants (551 deaths) in the Jackson Heart Study (JHS) were analyzed. Cox regression models were used to perform survival analysis. Obesity measures were analyzed as dichotomous (obese/non-obese) and continuous variables. Baseline covariates included age, sex and smoking status.
resultsComparing obese to non-obese participants, adjusted hazard ratios (95% CI) for overall mortality were 1.14 (0.96, 1.35), 1.30 (1.07, 1.59), 1.02 (0.73, 1.41) and 1.45 (1.18, 1.79) when using BMI, WC, WHtR and WHR, respectively. For BMI, WC and WHtR, a J-shaped relationship was observed with overall mortality. For WHR, a monotonic increasing relationship was observed with overall mortality.
conclusionsIn the JHS, we found that obesity as defined by WC and WHR was associated with an increased risk of overall and CVD mortality, while obesity defined by BMI was associated only with an increased risk of CVD mortality. WHR was the only obesity measure that showed a monotonic increasing relationship with overall and CVD mortality.
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