ArticleBMC pediatrics2021
Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: the IVHU study.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Prevalence and risk of adverse intrapartum-related outcomes in Uganda: a cross-sectional study with nested case-control.BMJ open · 2025Article
- Intraventricular haemorrhage, associated factors and mortality among very low birth weight neonates admitted at Muhimbili National Hospital, Dar es Salaam, Tanzania: a prospective cohort study.Italian journal of pediatrics · 2025Article
- Prevalence of intraventricular hemorrhage and associated factors to in premature babies in selected teaching hospitals in Rwanda.BMC pediatrics · 2025Article
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- Risk factors associated with intraventricular hemorrhage in very-low-birth-weight premature infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Magnitude and associated factors of intraventricular hemorrhage in preterm neonates admitted to low resource settings: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Intraventricular hemorrhage prediction in premature neonates in the era of hemodynamics monitoring: a prospective cohort study.European journal of pediatrics · 2022Observational
- The Impact of Different Degrees of Intraventricular Hemorrhage on Mortality and Neurological Outcomes in Very Preterm Infants: A Prospective Cohort Study.Frontiers in neurology · 2022Article
- Effect of surgical treatment on prognosis in preterm infants with obstructive hydrocephalus.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundGlobally, 15 million neonates are born prematurely every year, over half in low income countries (LICs). Premature and low birth weight neonates have a higher risk of intraventricular haemorrhage (IVH). There are minimal data regarding IVH in sub-Saharan Africa. This study aimed to examine the incidence, severity and timing of and modifiable risk factors for IVH amongst low-birth-weight neonates in Uganda.
methodsThis is a prospective cohort study of neonates with birthweights of ≤2000 g admitted to a neonatal unit (NU) in a regional referral hospital in eastern Uganda. Maternal data were collected from interviews and medical records. Neonates had cranial ultrasound (cUS) scans on the day of recruitment and days 3, 7 and 28 after birth. Risk factors were tabulated and are presented alongside odds ratios (ORs) and adjusted odds ratios (aORs) for IVH incidence. Outcomes included incidence, timing and severity of IVH and 28-day survival.
resultsOverall, 120 neonates were recruited. IVH was reported in 34.2% of neonates; 19.2% had low grade (Papile grades 1-2) and 15% had high grade (Papile grades 3-4). Almost all IVH (90.2%) occurred by day 7, including 88.9% of high grade IVH. Of those with known outcomes, 70.4% (81/115) were alive on day 28 and survival was not associated with IVH. We found that vaginal delivery, gestational age (GA) < 32 weeks and resuscitation in the NU increased the odds of IVH. Of the 6 neonates who received 2 doses of antenatal steroids, none had IVH.
conclusionIn this resource limited NU in eastern Uganda, more than a third of neonates born weighing ≤2000 g had an IVH and the majority of these occurred by day 7. We found that vaginal birth, earlier gestation and need for resuscitation after admission to the NU increased the risk of IVH. This study had a high rate of SGA neonates and the risk factors and relationship of these factors with IVH in this setting needs further investigation. The role of antenatal steroids in the prevention of IVH in LICs also needs urgent exploration.
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