ArticleBMC pregnancy and childbirth2021
The onset of nausea and vomiting of pregnancy: a prospective cohort study.
Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01577147 (Generic Protocol for the Collection of Early Pregnancy Urines), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Generic Protocol for the Collection of Early Pregnancy Urines
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Sedentary Behavior on the Complications Experienced by Pregnant Women: A Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- The gut microbiome in early pregnancy is associated with the severity of nausea and vomiting: a nested case‒control study.Gut microbes reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period
methodsProspective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting.
resultsAlmost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation.
conclusionsOnset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface.
trial registrationNCT01577147 . Date of registration 13 April 2012.
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