Evidence map›Paper›PMID 33407156›Full record

Trial reportBMC anesthesiology2021

Effects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial.

Siqi Xu, Shenghong Hu, Xia Ju, Yuanhai Li, Qing Li, Shengbin Wang

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03276533 nacompletednot on this map

Effects of Intravenous Dexmedetomidine, Lidocaine and Their Combination on Postoperative Inflammation Cytokines After Laparoscopic Hysterectomy With General Anesthesia

TypeinterventionalSponsorAnqing Municipal HospitalRan2017 to 2020Enrolled160ConditionsAnesthesia, ReactionArmsSaline, Lidocaine, Dexmedetomidine, Lidocaine plus Dexmedetomidine
NCT07073846 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled104ConditionsMorbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative AnalgesiaArmsIntravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia, 0.9 % Saline Placebo + Standard Anesthesia
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  17. Mechanism, Dose, and Administration of Dexmedetomidine in Managing Visceral Pain Associated With Surgery: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Siqi XuDepartment of Anesthesiology, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 246000, China.
Shenghong HuDepartment of Anesthesiology, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 246000, China.
Xia JuDepartment of Anesthesiology, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 246000, China.
Yuanhai LiDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
Qing LiDepartment of Gynaecology and Obstetrics, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 246000, China.
Shengbin WangDepartment of Anesthesiology, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 246000, China. shbw1965@126.com.ORCID 0000-0003-4827-3705
Anhui Medical University · CN

Funding

Clinical Research Fund of Anhui Medical University 2019xkj224
6 · The paper itself

Abstract

backgroundSurgical-related inflammatory responses have negative effects on postoperative recovery. Intravenous (IV) lidocaine and dexmedetomidine inhibits the inflammatory response. We investigated whether the co-administration of lidocaine and dexmedetomidine could further alleviate inflammatory responses compared with lidocaine or dexmedetomidine alone during laparoscopic hysterectomy.

methodsA total of 160 patients were randomly allocated into four groups following laparoscopic hysterectomy: the control group (group C) received normal saline, the lidocaine group (group L) received lidocaine (bolus infusion of 1.5 mg/kg over 10 min, 1.5 mg/kg/h continuous infusion), the dexmedetomidine group (group D) received dexmedetomidine (bolus infusion of 0.5 μg/kg over 10 min, 0.4 μg/kg/h continuous infusion), and the lidocaine plus dexmedetomidine group (group LD) received a combination of lidocaine (bolus infusion of 1.5 mg/kg over 10 min, 1.5 mg/kg/h continuous infusion) and dexmedetomidine (bolus infusion of 0.5 μg/kg over 10 min, 0.4 μg/kg/h continuous infusion). The levels of plasma interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) at different time points were the primary outcomes. Secondary outcomes included hemodynamic variables, postoperative visual analogue scale (VAS) scores, time to first flatus, and incidence of nausea and vomiting after surgery.

resultsThe levels of plasma IL-1, IL-6, and TNF-α were lower in groups D and LD than in group C and were lowest in group LD at the end of the procedure and 2 h after the operation (P < 0.05). The VAS scores were decreased in groups D and LD compared with group C (P < 0.05). The heart rate (HR) was decreased at the end of the procedure and 2 h after the operation in groups D and LD compared to groups C and L (P < 0.001). The mean blood pressure (MBP) was lower at 2 h after the operation in groups L, D, and LD than in group C (P < 0.001). There was a lower incidence of postoperative nausea and vomiting (PONV) in group LD than in group C (P < 0.05).

conclusionsThe combination of lidocaine and dexmedetomidine significantly alleviated the inflammatory responses, decreased postoperative pain, and led to fewer PONV in patients undergoing laparoscopic hysterectomy.

trial registrationClinicalTrials.gov ( NCT03276533 ), registered on August 23, 2017.

Indexed as

HysterectomyAnalgesics, Non-NarcoticAnesthetics, LocalDexmedetomidineDrug Therapy, CombinationFemaleHumansInflammationInfusions, IntravenousInterleukin-1Interleukin-6LaparoscopyLidocaineMiddle AgedPostoperative Nausea and VomitingPostoperative PainAnalgesics, Non-NarcoticAnesthetics, LocalDexmedetomidineInterleukin-1Interleukin-6LidocaineTumor Necrosis Factor-alphaDexmedetomidineInterleukinLaparoscopic hysterectomyLidocaineTumor necrosis factor-α

Identifiers

PMID33407156
PMCPMC7786488
OpenAlexW3118339499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.