ArticleBMC microbiology2021
The type VI secretion system of Xanthomonas phaseoli pv. manihotis is involved in virulence and in vitro motility.
Article in BMC microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Neisseria subflava Type 6 Secretion System competition with bacterial and fungal species.Applied microbiology and biotechnology · 2026Article
- Review
- TheISME communications · 2025Article
- The Role of ClpV in the Physiology and Pathogenicity ofMicroorganisms · 2024Article
- T6SS in plant pathogens: unique mechanisms in complex hosts.Infection and immunity · 2024Review
- The role of the type VI secretion system in the stress resistance of plant-associated bacteria.Stress biology · 2024Review
- Transcriptome profiling of type VI secretion system core geneMicrobiology spectrum · 2024Article
- Two novelFrontiers in microbiology · 2024Article
- The type VI secretion system of Stenotrophomonas rhizophila CFBP13503 limits the transmission of Xanthomonas campestris pv. campestris 8004 from radish seeds to seedlings.Molecular plant pathology · 2024Article
- Antagonistic transcriptome profile reveals potential mechanisms of action onFrontiers in cellular and infection microbiology · 2023Article
- HpaP divergently regulates the expression of hrp genes in Xanthomonas oryzae pathovars oryzae and oryzicola.Molecular plant pathology · 2023Article
- Transcriptional regulator Sar regulates the multiple secretion systems in Xanthomonas oryzae.Molecular plant pathology · 2023Article
- H3-T6SS of Pseudomonas aeruginosa PA14 contributes to environmental adaptation via secretion of a biofilm-promoting effector.Stress biology · 2022Article
- Comparative genome analysis unravels pathogenicity of Xanthomonas albilineans causing sugarcane leaf scald disease.BMC genomics · 2022Article
- RpoN/Sfa2-dependent activation of the Pseudomonas aeruginosa H2-T6SS and its cognate arsenal of antibacterial toxins.Nucleic acids research · 2022Article
- Phylogenetic Distribution and Evolution of Type VI Secretion System in the GenusFrontiers in microbiology · 2022Article
- Article
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundThe type VI protein secretion system (T6SS) is important in diverse cellular processes in Gram-negative bacteria, including interactions with other bacteria and with eukaryotic hosts. In this study we analyze the evolution of the T6SS in the genus Xanthomonas and evaluate its importance of the T6SS for virulence and in vitro motility in Xanthomonas phaseoli pv. manihotis (Xpm), the causal agent of bacterial blight in cassava (Manihot esculenta). We delineate the organization of the T6SS gene clusters in Xanthomonas and then characterize proteins of this secretion system in Xpm strain CIO151.
resultsWe describe the presence of three different clusters in the genus Xanthomonas that vary in their organization and degree of synteny between species. Using a gene knockout strategy, we also found that vgrG and hcp are required for maximal aggressiveness of Xpm on cassava plants while clpV is important for both motility and maximal aggressiveness.
conclusionWe characterized the T6SS in 15 different strains in Xanthomonas and our phylogenetic analyses suggest that the T6SS might have been acquired by a very ancient event of horizontal gene transfer and maintained through evolution, hinting at their importance for the adaptation of Xanthomonas to their hosts. Finally, we demonstrated that the T6SS of Xpm is functional, and significantly contributes to virulence and motility. This is the first experimental study that demonstrates the role of the T6SS in the Xpm-cassava interaction and the T6SS organization in the genus Xanthomonas.
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