ArticleJournal of neurodevelopmental disorders2021
Associations between sensory processing and electrophysiological and neurochemical measures in children with ASD: an EEG-MRS study.
Article in Journal of neurodevelopmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Neurometabolite differences in Autism as assessed with Magnetic Resonance Spectroscopy: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Resting-state EEG power differences in autism spectrum disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- Sensory Reactivity in Autism: Integrating Behavioural, Affective, Physiological, and Neural Dimensions.Current psychiatry reports · 2026Review
- The developmental trajectory of EEG alpha coherence in autistic toddlers with and without language delay.medRxiv : the preprint server for health sciences · 2026Article
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- QEEG-Guided rTMS in Pediatric ASD with Contextual Evidence on Home-Based tDCS: Within-Cohort Reanalysis and Narrative Contextualization.Children (Basel, Switzerland) · 2025Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Brain Complexity and Parametrization of Power Spectral Density in Children with Specific Language Impairment.Entropy (Basel, Switzerland) · 2025Article
- The role of anxiety in modulating temporal processing and sensory hyperresponsiveness in autism spectrum disorder: an fMRI study.Scientific reports · 2025Article
- Multi-level treatment outcome evaluation in adolescents with autism spectrum disorder.Child and adolescent psychiatry and mental health · 2025Article
- Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach.PLoS computational biology · 2025Article
- Increased alpha power in autistic adults: Relation to sensory behaviors and cortical volume.Autism research : official journal of the International Society for Autism Research · 2025Article
- Atypical Sensory Processing in Neurodevelopmental Disorders: Clinical Phenotypes in Preschool-Aged Children.Children (Basel, Switzerland) · 2024Article
- 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project.Frontiers in psychology · 2024Article
- Comparison of autism spectrum disorder subtypes based on functional and structural factors.Frontiers in neuroscience · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Linear and Non-linear Analyses of EEG in a Group of ASD Children During Resting State Condition.Brain topography · 2023Article
- TheFrontiers in behavioral neuroscience · 2023Article
- Intellectually able adults with autism spectrum disorder show typical resting-state EEG activity.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAutism spectrum disorder (ASD) is associated with hyper- and/or hypo-sensitivity to sensory input. Spontaneous alpha power, which plays an important role in shaping responsivity to sensory information, is reduced across the lifespan in individuals with ASD. Furthermore, an excitatory/inhibitory imbalance has also been linked to sensory dysfunction in ASD and has been hypothesized to underlie atypical patterns of spontaneous brain activity. The present study examined whether resting-state alpha power differed in children with ASD as compared to TD children, and investigated the relationships between alpha levels, concentrations of excitatory and inhibitory neurotransmitters, and atypical sensory processing in ASD.
methodsParticipants included thirty-one children and adolescents with ASD and thirty-one age- and IQ-matched typically developing (TD) participants. Resting-state electroencephalography (EEG) was used to obtain measures of alpha power. A subset of participants (ASD = 16; TD = 16) also completed a magnetic resonance spectroscopy (MRS) protocol in order to measure concentrations of excitatory (glutamate + glutamine; Glx) and inhibitory (GABA) neurotransmitters.
resultsChildren with ASD evidenced significantly decreased resting alpha power compared to their TD peers. MRS estimates of GABA and Glx did not differ between groups with the exception of Glx in the temporal-parietal junction. Inter-individual differences in alpha power within the ASD group were not associated with region-specific concentrations of GABA or Glx, nor were they associated with sensory processing differences. However, atypically decreased Glx was associated with increased sensory impairment in children with ASD.
conclusionsAlthough we replicated prior reports of decreased alpha power in ASD, atypically reduced alpha was not related to neurochemical differences or sensory symptoms in ASD. Instead, reduced Glx in the temporal-parietal cortex was associated with greater hyper-sensitivity in ASD. Together, these findings may provide insight into the neural underpinnings of sensory processing differences present in ASD.
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