ArticleEmerging microbes & infections2021
Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission.
Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 67 citations in OpenAlex.
- COVID-19 re-infection: a large cross-sectional population-based study in the northeast of Iran.BMC infectious diseases · 2025Article
- Article
- SARS-CoV-2 infection in animals: Patterns, transmission routes, and drivers.Eco-Environment & Health · 2024Review
- The serological IgG and neutralizing antibody of SARS-CoV-2 omicron variant reinfection in Jiangsu Province, China.Frontiers in public health · 2024Article
- Clinical and prognostic implications of hyaluronic acid in patients with COVID-19 reinfection and first infection.Frontiers in microbiology · 2024Article
- RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses against SARS-CoV-2 in Cynomolgus Macaques.Vaccines · 2023Article
- The panzootic potential of SARS-CoV-2.Bioscience · 2023Article
- SARS-CoV-2 transmission in teenagers and young adults in Fútbol Club Barcelona's Multidisciplinary Sports Training Academy.European journal of pediatrics · 2023Observational
- COVID-19 Reinfection Rate and Related Risk Factors in Fars Province, Iran: A Retrospective Cohort Study.Iranian journal of medical sciences · 2023Article
- Ferrets: A powerful model of SARS-CoV-2.Zoological research · 2023Review
- Validation of a SARS-CoV-2 Surrogate Virus Neutralization Test in Recovered and Vaccinated Healthcare Workers.Viruses · 2023Article
- AZD1222-induced nasal antibody responses are shaped by prior SARS-CoV-2 infection and correlate with virologic outcomes in breakthrough infection.Cell reports. Medicine · 2023Article
- Longitudinal analysis of SARS-CoV-2 reinfection reveals distinct kinetics and emergence of cross-neutralizing antibodies to variants of concern.Frontiers in microbiology · 2023Article
- Evaluation of humoral immune response in relation to COVID-19 severity over 1 year post-infection: critical cases higher humoral immune response than mild cases.Frontiers in immunology · 2023Article
- Mitigation of COVID-19 at the 2021 National Collegiate Athletic Association Men's Basketball Tournament.BMC public health · 2022Article
- SARS-CoV-2 indoor environment contamination with epidemiological and experimental investigations.Indoor air · 2022Article
- Kinetics of neutralizing antibodies against SARS-CoV-2 infection according to sex, age, and disease severity.Scientific reports · 2022Article
- Clinical Characteristics and Outcomes of Patients With SARS-CoV-2 Reinfection.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- Risk of SARS-CoV-2 transmission upon return to work in RNA-positive healthcare workers.The Journal of hospital infection · 2022Article
- BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 andVaccines · 2022Article
Corrections and comments
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Authors and funding
24 authors at 4 institutions in 2 countries.
Funding
Abstract
Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number of countries. Further, the level of natural immunity induced by SARS-CoV-2 infection is not fully clear, nor is it clear if a primary infection is protective against reinfection. To investigate the potential association between serum antibody titres and reinfection of SARS-CoV-2, ferrets with different levels of NAb titres after primary SARS-CoV-2 infection were subjected to reinfection with a heterologous SARS-CoV-2 strain. All heterologous SARS-CoV-2 reinfected ferrets showed active virus replication in the upper respiratory and gastro-intestinal tracts. However, the high NAb titre group showed attenuated viral replication and rapid viral clearance. In addition, direct-contact transmission was observed only from reinfected ferrets with low NAb titres (<20), and not from other groups. Further, lung histopathology demonstrated the presence of limited inflammatory regions in the high NAb titre groups compared with control and low NAb groups. This study demonstrates a close correlation between a low NAb titre and SARS-CoV-2 reinfection in a recovered ferret reinfection model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.