Evidence map›Paper›PMID 33406950›Full record

ArticleJournal of psychopharmacology (Oxford, England)2021

Acute acetate administration increases endogenous opioid levels in the human brain: A [

Abhishekh H Ashok, Jim Myers, Gary Frost, Samuel Turton, Roger N Gunn, Jan Passchier, Alessandro Colasanti, Tiago Reis Marques, David Nutt, Anne Lingford-Hughes and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Abhishekh H AshokPsychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Imperial College London, London, UK.ORCID 0000-0003-3636-7253
Jim MyersImperial College London, UK.
Gary FrostImperial College London, UK.
Samuel TurtonImperial College London, UK.
Roger N GunnImperial College London, UK.
Jan PasschierInvicro, London, UK.
Alessandro ColasantiDepartment of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.ORCID 0000-0001-6017-801X
Tiago Reis MarquesPsychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Imperial College London, London, UK.
David NuttImperial College London, UK.
Anne Lingford-HughesImperial College London, UK.
Oliver D HowesPsychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Imperial College London, London, UK.
Eugenii A RabinerInstitute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
King's College London · GBImperial College London · GBInvicro (United Kingdom) · GBBrighton and Sussex Medical School · GB

Funding

Medical Research Council MC_U120097115Medical Research Council MR/N00616X/1Medical Research Council MR/N027078/1Wellcome Trust
6 · The paper itself

Abstract

introductionA recent study has shown that acetate administration leads to a fourfold increase in the transcription of proopiomelanocortin (POMC) mRNA in the hypothalamus. POMC is cleaved to peptides, including β-endorphin, an endogenous opioid (EO) agonist that binds preferentially to the µ-opioid receptor (MOR). We hypothesised that an acetate challenge would increase the levels of EO in the human brain. We have previously demonstrated that increased EO release in the human brain can be detected using positron emission tomography (PET) with the selective MOR radioligand [

methodsSeven volunteers each completed a baseline [

resultsFollowing sodium acetate administration, 2.5-6.5% reductions in [

conclusionsWe have demonstrated that an acute acetate challenge has the potential to increase EO release in the human brain, providing a plausible mechanism of the central effects of acetate on appetite in humans.

Indexed as

AdultAnalgesics, OpioidBrainCarbon RadioisotopesFentanylHumansMaleMiddle AgedOpioid PeptidesPositron-Emission TomographyReceptors, OpioidSodium AcetateAnalgesics, OpioidCarbon RadioisotopescarfentanilFentanylOpioid PeptidesReceptors, OpioidSodium AcetateAcetateopioidPET

Identifiers

PMID33406950
PMCPMC8155733
OpenAlexW3120705087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.