Evidence map›Paper›PMID 33406941›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant

Zainab M Elsayed, Wagdy M Eldehna, Marwa M Abdel-Aziz, Mahmoud A El Hassab, Eslam B Elkaeed, Tarfah Al-Warhi, Hatem A Abdel-Aziz, Sahar M Abou-Seri, Eman R Mohammed

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Discovery of novel anti-RSC advances · 2026
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  6. Review
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  8. Identification of sulphonamide-tetheredJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
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  12. A review of the global climate change impacts, adaptation, and sustainable mitigation measures.Environmental science and pollution research international · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zainab M ElsayedFaculty of Pharmacy, Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt.
Wagdy M EldehnaFaculty of Pharmacy, Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt.
Marwa M Abdel-AzizThe Regional Center for Mycology & Biotechnology, Al-Azhar University, Cairo, Egypt.
Mahmoud A El HassabDepartment of Pharmaceutical Chemistry, School of Pharmacy, Badr University in Cairo, Badr City, Egypt.
Eslam B ElkaeedDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia.
Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Hatem A Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center, Giza, Egypt.
Sahar M Abou-SeriFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Cairo University, Cairo, Egypt.
Eman R MohammedFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (

Indexed as

Alcohol OxidoreductasesAnti-Bacterial AgentsBacterial ProteinsBinding SitesBordetella pertussisBronchitisDrug DesignDrug Resistance, BacterialHaemophilus influenzaeHydrazinesIsatinIsoniazidKlebsiella pneumoniaeMicrobial Sensitivity TestsMolecular Docking SimulationMoraxella catarrhalisAlcohol OxidoreductasesAnti-Bacterial AgentsBacterial ProteinsDprE1 protein, Mycobacterium tuberculosisHydrazinesIsatinIsoniazidStreptomycinAnti-tubercular activityDprE1 inhibitorsisatin derivativesnicotinohydrazideresistant TB

Identifiers

PMID33406941
PMCPMC7801109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.