ArticleObstetrics & gynecology science2021
Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review.
Article in Obstetrics & gynecology science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials.Nutrients · 2024Pooled it
- The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review.Journal of medicine and life · 2023Pooled it
- Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Nutrients · 2023Pooled it
- The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial.BMC women's health · 2023Trial
- Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study.BMC complementary medicine and therapies · 2022Trial
- Dietary Acid Load, Empirical Dietary Inflammatory Index, and Literature-Based Adherence to Mediterranean Diet Score Relationship With Primary Dysmenorrhea.Food science & nutrition · 2026Article
- Long-Term Management and Prevention Strategies for Adolescent Primary Dysmenorrhea: From Precision Diagnosis to Comprehensive Intervention.International journal of women's health · 2026Review
- Curcumin, a bioactive supplement for premenstrual syndrome and dysmenorrhea: A systematic review of randomised clinical trials.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- The effect of vitamin D on adolescents' primary dysmenorrhea.Journal of medicine and life · 2023Article
- The impact of primary dysmenorrhea on adolescents' activities and school attendance.Journal of medicine and life · 2023Article
- High prevalence of hypovitaminosis D3 among pregnant women in central Iran: correlation with newborn vitamin D3 levels and negative association with gestational age.Obstetrics & gynecology science · 2023Article
- Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea.BMC women's health · 2023Article
- Vitamin Effects in Primary Dysmenorrhea.Life (Basel, Switzerland) · 2023Review
- Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial.Obstetrics & gynecology science · 2023Article
- Disease Burden of Dysmenorrhea: Impact on Life Course Potential.International journal of women's health · 2023Review
- Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial.Obstetrics & gynecology science · 2021Article
- Nutrition in Gynecological Diseases: Current Perspectives.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysmenorrhea is one of the well-established problems among women of reproductive age and can have adverse effects on the quality of life of the individual. Some studies suggest a relationship between vitamin D (Vit D) and calcium deficiency and the emergence of early dysmenorrhea. Accordingly, a systematic study was performed to investigate the role of calcium and Vit D in the relief of primary dysmenorrhea. A systematic literature search was performed in PubMed, Web of Science, Scopus, Science Direct, and Google Scholar for papers published between 2010 and 2020. The Consolidated Standards of Reporting Trials and Strengthening the Reporting of Observational Studies in Epidemiology checklists were used to assess the quality of the studies. The risk of bias was assessed using the Cochrane risk-of-bias assessment tool. Low calcium levels lead to an increase in uterine muscle contraction and can cause pain after decreased uterine blood flow. Furthermore, low levels of Vit D can increase primary dysmenorrhea by increasing prostaglandin production or reducing intestinal calcium absorption. That being the case, Vit D and calcium intake can be effective in reducing the severity of primary dysmenorrhea and in reducing the rate of analgesic use. Low levels of Vit D and calcium are inversely related to the severity of primary dysmenorrhea, and Vit D and calcium intake can reduce the severity of primary dysmenorrhea and its associated systemic symptoms. Therefore, the use of calcium and Vit D supplements can be recommended to relieve dysmenorrhea.
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Registered trials
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