ArticlePolymers2021
Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Amygdalin-Doped Biopolymer Composites as Potential Wound Dressing Films: In Vitro Study onGels (Basel, Switzerland) · 2025Article
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- Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy.Frontiers in chemistry · 2025Article
- Methylene Blue Solid Alginate Gels for Photodynamic Therapy: The Peculiarities of Production and Controlled Release of the Dye.Polymers · 2024Article
- Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices.Pharmaceutics · 2024Article
- Polymeric nanocomposite hydrogel scaffold for jawbone regeneration: The role of rosuvastatin calcium-loaded silica nanoparticles.International journal of pharmaceutics: X · 2023Article
- Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis.Inflammopharmacology · 2023Article
- Synthesis and Characterization of Polymer-Based Membranes for Methotrexate Drug Delivery.Polymers · 2023Article
- A novel study for producing complexed and encapsulated nutrients at nanometric scale to enhance plant growth.Scientific reports · 2023Article
- A Plant-Based Animal Fat Analog Produced by an Emulsion Gel of Alginate and Pea Protein.Gels (Basel, Switzerland) · 2023Article
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- Injectable Networks Based on a Hybrid Synthetic/Natural Polymer Gel and Self-Assembling Peptides Functioning as Reinforcing Fillers.Polymers · 2023Article
- Preliminary Study of κ-Carrageenan Based Membranes for Anti-Inflammatory Drug Delivery.Polymers · 2022Article
- Immobilization Systems of Antimicrobial Peptide Ib-M1 in Polymeric Nanoparticles Based on Alginate and Chitosan.Polymers · 2022Article
- Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma.Materials (Basel, Switzerland) · 2022Article
- Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine.Polymers · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this study is to obtain and characterize of alginate-based membranes, as well as to choose the most suitable membrane type for the transdermal release of methotrexate. The paper presents the synthesis of four types of membranes based on alginate to which are added other copolymers (Carbopol, Tween, and Polyvinylpyrrolidone) as well as other components with different roles. Membranes and binary mixtures made between the components used in membrane synthesis and methotrexate are analyzed by thermogravimetric techniques, FTIR and UV spectroscopic techniques as well as SEM. The analyses aim to establish the type of membrane most indicated in the use of the controlled release of methotrexate, namely those membranes in which there are no interactions that could inactivate the active substance. Following these studies, it was concluded that membranes obtained from alginate/alginate and Tw can be used for methotrexate release. The membrane obtained from alginate and carbopol was excluded from the beginning because it is not homogeneous. Regarding the AGP-MTX membrane, it presents interactions with the active substance, carboxylate group interactions argued by TGA and FTIR studies, and interactions that occur in aqueous medium.
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Registered trials
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