Evidence map›Paper›PMID 33406760›Full record

ArticlePharmaceutics2021

Evaluation of Direct and Cell-Mediated Lactoferrin Gene Therapy for the Maxillofacial Area Abscesses in Rats.

Elima Agatieva, Said Ksembaev, Mikhail Sokolov, Vage Markosyan, Ilnaz Gazizov, Dmitry Tsyplakov, Maxim Shmarov, Irina Tutykhina, Boris Naroditsky, Denis Logunov and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Elima AgatievaDepartment of Maxillofacial Surgery and Surgical Dentistry, Kazan State Medical University, 420012 Kazan, Russia.
Said KsembaevDepartment of Maxillofacial Surgery and Surgical Dentistry, Kazan State Medical University, 420012 Kazan, Russia.
Mikhail SokolovDepartment of Operative Surgery and Topographic Anatomy, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0003-2938-6683
Vage MarkosyanDepartment of Operative Surgery and Topographic Anatomy, Kazan State Medical University, 420012 Kazan, Russia.
Ilnaz GazizovDepartment of Operative Surgery and Topographic Anatomy, Kazan State Medical University, 420012 Kazan, Russia.
Dmitry TsyplakovDepartment of Pathology, Kazan State Medical University, 420012 Kazan, Russia.
Maxim ShmarovThe National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-5268-1296
Irina TutykhinaThe National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Boris NaroditskyThe National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Denis LogunovThe National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Oskar PozdeevDepartment of Microbiology, Kazan State Medical Academy, 420012 Kazan, Russia.
Lidiya MorozovaDepartment of Microbiology, Kazan State Medical Academy, 420012 Kazan, Russia.
Kamilya YapparovaDepartment of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia.
Rustem IslamovDepartment of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0002-6632-4636
Kazan State Medical University · RUMinistry of Health of the Russian Federation · RUKazan State Medical Academy · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to antibacterial therapy requires the discovery of new methods for the treatment of infectious diseases. Lactoferrin (LTF) is a well-known naïve first-line defense protein. In the present study, we suggested the use of an adenoviral vector (Ad5) carrying the human gene encoding LTF for direct and cell-mediated gene therapy of maxillofacial area phlegmon in rats. Abscesses were developed by injection of the purulent peritoneal exudate in the molar region of the medial surface of the mandible. At 3-4 days after phlegmon maturation, all rats received ceftriaxone and afterward were subcutaneously injected around the phlegmon with: (1) Ad5 carrying reporter

Indexed as

adenoviral vectorgene therapyhuman umbilical cord blood mononuclear celllactoferrin genelymph nodemaxillofacial area phlegmonratwound healing

Identifiers

PMID33406760
PMCPMC7823524
OpenAlexW3118259942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.