Evidence map›Paper›PMID 33406667›Full record

ArticleMetabolites2021

Metabolic Detoxification of 2-Oxobutyrate by Remodeling

Yu Fang, Shuyan Zhang, Jianli Wang, Lianghong Yin, Hailing Zhang, Zhen Wang, Jie Song, Xiaoqing Hu, Xiaoyuan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yu FangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Shuyan ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jianli WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Lianghong YinZhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Zhejiang A&F University, Hangzhou 311300, China.
Hailing ZhangDepartment of Biological Engineering, College of Life Science, Yantai University, Yantai 264005, China.
Zhen WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jie SongState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Xiaoqing HuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Xiaoyuan WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-0875-8230
Jiangnan University · CNYantai University · CNZhejiang A & F University · CN

Funding

National First-class Discipline Program of Light Industry Technology and Engineering LITE2018-10National Key R&D Program of China 2018YFA0900300
6 · The paper itself

Abstract

2-Oxobutyrate (2-OBA), as a toxic metabolic intermediate, generally arrests the cell growth of most microorganisms and blocks the biosynthesis of target metabolites. In this study, we demonstrated that using the acetate bypass to replace the pyruvate dehydrogenase complex (PDHc) in

Indexed as

2-oxobutyrateacetate bypassEscherichia colimetabolic detoxificationpyruvate oxidase

Identifiers

PMID33406667
PMCPMC7824062
OpenAlexW3120773747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.