Evidence map›Paper›PMID 33406653›Full record

ArticleSensors (Basel, Switzerland)2021

Oxygen Saturation Imaging Using LED-Based Photoacoustic System.

Rianne Bulsink, Mithun Kuniyil Ajith Singh, Marvin Xavierselvan, Srivalleesha Mallidi, Wiendelt Steenbergen, Kalloor Joseph Francis

Erratum issuedAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  18. Biomedical optics express · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Rianne BulsinkBiomedical Photonic Imaging (BMPI), Technical Medical Center, University of Twente, 7500 AE Enschede, The Netherlands.
Mithun Kuniyil Ajith SinghResearch & Business Development Division, CYBERDYNE Inc., Cambridge Innovation Center, 3013 AK Rotterdam, The Netherlands.ORCID 0000-0001-8670-6335
Marvin XavierselvanDepartment of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, MA 02155, USA.ORCID 0000-0002-8361-7318
Srivalleesha MallidiDepartment of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, MA 02155, USA.ORCID 0000-0003-1547-1764
Wiendelt SteenbergenBiomedical Photonic Imaging (BMPI), Technical Medical Center, University of Twente, 7500 AE Enschede, The Netherlands.ORCID 0000-0003-3452-6791
Kalloor Joseph FrancisBiomedical Photonic Imaging (BMPI), Technical Medical Center, University of Twente, 7500 AE Enschede, The Netherlands.ORCID 0000-0001-9766-7140

Funding

National Centre for the Replacement, Refinement and Reduction of Animals in Research CRACKITRT-P1-3The 4TU Precision Medicine Program, of the technical universities in the Netherlands UT
6 · The paper itself

Abstract

Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6-8 mm in both preclinical and clinical applications.

Indexed as

fluence compensationhypoxiain vivoLEDoxygen saturation imagingphotoacousticsultrasound

Identifiers

PMID33406653
PMCPMC7795655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.