Evidence map›Paper›PMID 33406506›Full record

ArticleAging2020

Human placenta-derived mesenchymal stem cells trigger repair system in TAA-injured rat model via antioxidant effect.

Jeeyoon Na, Joseph Song, Hyun Ho Kim, Jin Seok, Jae Yeon Kim, Ji Hye Jun, Gi Jin Kim

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jeeyoon NaDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joseph SongDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Hyun Ho KimCollege of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Jin SeokDepartment of Biomedical Science, CHA University, Seongnam, Republic of Korea.
Jae Yeon KimDepartment of Biomedical Science, CHA University, Seongnam, Republic of Korea.
Ji Hye JunDepartment of Biomedical Science, CHA University, Seongnam, Republic of Korea.
Gi Jin KimDepartment of Biomedical Science, CHA University, Seongnam, Republic of Korea.
CHA University · KRUniversity of California San Diego · USUniversity of Illinois Urbana-Champaign · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress induces damages of various cell types or tissues through a repetitive imbalance between the systemic manifestation of reactive oxygen species (ROS) and detoxification of the reactive intermediates. Thioacetamide (TAA) is well known for causing several degenerative diseases by oxidative stress. However, study of the antioxidant mechanisms of stem cells in TAA-injured rat model is insufficient. Therefore, we investigated the effect of placenta-derived mesenchymal stem cells (PD-MSCs) transplantation on liver and ovary of TAA-injured rat models to study the antioxidant effect in degenerative diseases. In TAA-injured rat model, PD-MSCs engrafted into damaged organ including liver and ovary in PD-MSCs transplanted groups (Tx) compared with non-transplanted groups (NTx) (*

Indexed as

Mesenchymal Stem Cell TransplantationOxidative StressAlbuminsAnimalsAntioxidantsChemical and Drug Induced Liver InjuryFemaleHeme Oxygenase (Decyclizing)HumansInflammationLiverLiver RegenerationMesenchymal Stem CellsNADPH Oxidase 4OvaryPlacentaAlbuminsAntioxidantsHeme Oxygenase (Decyclizing)Hmox1 protein, ratNADPH Oxidase 4Nox4 protein, ratReactive Oxygen SpeciesThioacetamideantioxidantsliverovaryplacenta-derived mesenchymal stem cellsthioacetamide

Identifiers

PMID33406506
PMCPMC7835021
OpenAlexW3116224876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.