Evidence map›Paper›PMID 33406429›Full record

ArticleCell reports2021

Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.

Daniel G Bunis, Yelena Bronevetsky, Elisabeth Krow-Lucal, Nirav R Bhakta, Charles C Kim, Srilaxmi Nerella, Norman Jones, Ventura F Mendoza, Yvonne J Bryson, James E Gern and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  11. Early-life human CD8Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  13. Gut-X axis.iMeta · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Daniel G BunisEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Yelena BronevetskyDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Elisabeth Krow-LucalDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Nirav R BhaktaDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Charles C KimDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Srilaxmi NerellaDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Norman JonesEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ventura F MendozaEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Yvonne J BrysonDivision of Pediatric Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine at UCLA, Mattel Children's Hospital UCLA, Los Angeles, CA, USA.
James E GernDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Rachel L RutishauserDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Chun Jimmie YeBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, Division of Neonatology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: marina.sirota@ucsf.edu.
Joseph M McCuneDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: mike.mccune@gatesfoundation.org.
Trevor D BurtEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, Division of Neonatology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: trevor.burt@duke.edu.
University of California, San Francisco · USBroad Center · USMattel Children's Hospital · USUniversity of Wisconsin–Madison · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Early Antiretroviral Therapy and HIV Remission in Perinatal InfectionR01HD080474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BRYSON, YVONNE J., LUZURIAGA, KATHERINE F · 2014 to 2018
$6.5M
HIV EFFECTS ON THE CENTRAL HEMATOLYMPHOID SYSTEMR37AI040312 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCUNE, JOSEPH M · 2000 to 2010
$5.0M
NIH Director's Pioneer Award (RMI)DP1OD000329 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCUNE, JOSEPH M · 2004 to 2008
$4.2M
Defining Transition from Fetal to Adult T Cell Predominance in the Human FetusK08HD067295 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURT, TREVOR DEON · 2011 to 2015
$628k
Elucidating the Role of the Genetic and Environmental Determinants of Preterm Birth Using Integrative Computational ApproachesK01LM012381 · NLM · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIROTA, MARINA · 2016 to 2018
$531k
Understanding Molecular Pathways for Fetal T Cell Development and FunctionR21AI120032 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURT, TREVOR DEON · 2015 to 2016
$436k
Human immune system layering and the neonatal response to vaccinesR21AI094009 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCUNE, JOSEPH M · 2011 to 2012
$425k
NIAID NIH HHS R21 AI094009NIAID NIH HHS R21 AI120032NIAID NIH HHS R37 AI040312NIAID NIH HHS T32 AI007334NIAID NIH HHS UM1 AI114271NIAMS NIH HHS P30 AR070155NICHD NIH HHS K08 HD067295NICHD NIH HHS R01 HD080474NIH HHS DP1 OD000329NLM NIH HHS K01 LM012381
6 · The paper itself

Abstract

Whereas the human fetal immune system is poised to generate immune tolerance and suppress inflammation in utero, an adult-like immune system emerges to orchestrate anti-pathogen immune responses in post-natal life. It has been posited that cells of the adult immune system arise as a discrete ontological "layer" of hematopoietic stem-progenitor cells (HSPCs) and their progeny; evidence supporting this model in humans has, however, been inconclusive. Here, we combine bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and HSPCs from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurs progressively along a continuum of maturity-with a substantial degree of inter-individual variation at the time of birth-rather than via a transition between discrete waves. These findings have important implications for the design of strategies for prophylaxis against infection in the newborn and for the use of umbilical cord blood (UCB) in the setting of transplantation.

Indexed as

Single-Cell AnalysisTranscriptomeBone MarrowCell Culture TechniquesFemaleFetal BloodFetusHematopoietic Stem CellsHumansImmunityLymphocytesMyeloid CellsPregnancySequence Analysis, RNAT-Lymphocytesdevelopmental stage scorehematopoietic ontogenyhematopoietic stem and progenitor cellshematopoietic stem cellshuman immune developmentmonocytesnaive T cellsnewborn immune developmentscRNA-seqsingle-cell RNA sequencing

Identifiers

PMID33406429
PMCPMC10263444
OpenAlexW3092742846

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.