Evidence map›Paper›PMID 33406370›Full record

ArticleAnnual review of neuroscience2021

Astrocytes and Behavior.

Paulo Kofuji, Alfonso Araque

Open access · greenAbstract read
In one paragraph

Article in Annual review of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 167 citations in OpenAlex.

  1. Article
  2. Cocaine facilitates CaMolecular psychiatry · 2026
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  3. Article
  4. Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Review
  6. Article
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  8. Article
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  11. Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Review
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  17. Article
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  19. Review
  20. Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paulo KofujiDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA; email: araque@umn.edu.
Alfonso AraqueDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA; email: araque@umn.edu.
University of Minnesota · US

Funding

Astrocyte activity in amygdala-related fear conditioned behaviorsR01MH119355 · NIMH · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, KOFUJI, PAULO · 2020 to 2024
$2.3M
Role of astrocytes in dopamine signaling and psychostimulant effectsR01DA048822 · NIDA · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO · 2019 to 2023
$1.8M
Astrocyte-neuron interaction in behavior driven by striatal information processingR01NS097312 · NINDS · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, REDISH, A DAVID · 2016 to 2019
$1.8M
NIDA NIH HHS R01 DA048822NIMH NIH HHS R01 MH119355NINDS NIH HHS R01 NS097312
6 · The paper itself

Abstract

Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, astrocytes are as numerous as neurons in the mammalian brain, and current findings indicate a chemically based dialog between astrocytes and neurons. Activation of astrocytes by synaptically released neurotransmitters converges on regulating intracellular Ca

Indexed as

AstrocytesSynaptic TransmissionAnimalsNeurogliaNeuronsSynapsesastrocytesbehaviorCa2+ signalinggliagliotransmissiontripartite synapse

Identifiers

PMID33406370
PMCPMC8257756
OpenAlexW3118953800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.