ArticleSleep2021
Association of objectively measured sleep with frailty and 5-year mortality in community-dwelling older adults.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of different sleep disorders on frailty in the elderly: a systematic review and meta-analysis of observational studies.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Systemic immune inflammation, physical function, and mortality in US adults: A prospective follow-up analysis of NHANES 2011 to 2014.Medicine · 2026Article
- Exploring bed sensor technology: interdisciplinary insights in a geriatric assessment inpatient setting.The Gerontologist · 2026Article
- Relationship between 24-h movement behaviors and frailty-a scoping review.Frontiers in public health · 2026Article
- Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.JHLT open · 2025Article
- Treatment Modalities for Insomnia in Adults Aged 55 and Older: A Systematic Review of Literature from 2018 to 2023.Current sleep medicine reports · 2024Article
- Lifestyle-related factors in late midlife as predictors of frailty from late midlife into old age: a longitudinal birth cohort study.Age and ageing · 2024Article
- Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.medRxiv : the preprint server for health sciences · 2024Article
- Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study.Sleep · 2024Article
- The relationship between sleep duration and frailty: findings from the China Health and Retirement Longitudinal Study.Frontiers in public health · 2024Article
- Is there a ubiquitous association between sleep disorder and frailty? findings from LASI (2017-18).BMC geriatrics · 2023Article
- Association of Sleep and Physical Activity Among Older Adults and the Moderation of Chronotype.International journal of aging & human development · 2023Article
- Article
- Dual trajectory of sleep and frail in elderly people.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Sleep and critical illness: a review.Frontiers in medicine · 2023Review
- Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study.BMC medicine · 2022Article
- Sleep habits are associated with cognition decline in physically robust, but not in frail participants: a longitudinal observational study.Scientific reports · 2022Observational
- Review
- Sleep duration and incident frailty: The Rural Frailty Study.BMC geriatrics · 2021Article
- Sex Differences in the Association Between Risk of Obstructive Sleep Apnea, Insomnia, and Frailty in Older Adults.Nature and science of sleep · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo determine whether actigraphy-measured sleep was independently associated with risk of frailty and mortality over a 5-year period among older adults.
methodsWe used data from Waves 2 (W2) and 3 (W3) (2010-2015) of the National Social Life, Health and Aging Project, a prospective cohort of community-dwelling older adults born between 1920 and 1947. One-third of W2 respondents were randomly selected to participate in a sleep study, of whom N = 727 consented and N = 615 were included in the analytic sample. Participants were instructed to wear a wrist actigraph for 72 h (2.93 ± 0.01 nights). Actigraphic sleep parameters were averaged across nights and included total sleep time, percent sleep, sleep fragmentation index, and wake after sleep onset. Subjective sleep was collected via questionnaire. Frailty was assessed using modified Fried Frailty Index. Vital status was ascertained at the time of the W3 interview. W3 frailty/mortality status was analyzed jointly with a four-level variable: robust, pre-frail, frail, and deceased. Associations were modeled per 10-unit increase.
resultsAfter controlling for baseline frailty (robust and pre-frail categories), age, sex, education, body mass index, and sleep time preference, a higher sleep fragmentation index was associated with frailty (OR = 1.70, 95% CI: 1.02-2.84) and mortality (OR = 2.12, 95% CI: 1.09-4.09). Greater wake after sleep onset (OR = 1.24, 95% CI: 1.02-1.50) and lower percent sleep (OR = 0.41, 95% CI: 0.17-0.97) were associated with mortality.
conclusionsAmong community-dwelling older adults, actigraphic sleep is associated with frailty and all-cause mortality over a 5-year period. Further investigation is warranted to elucidate the physiological mechanisms underlying these associations.
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