ArticleJCO global oncology2021
Conceptual Framework to Guide Early Diagnosis Programs for Symptomatic Cancer as Part of Global Cancer Control.
Article in JCO global oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05876676 (Rapid Diagnostic Centre Biomarker Study), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rapid Diagnostic Centre Biomarker Study
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Article
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- Exploring the policy implementation of a holistic approach to cancer investigation in non-specific symptom pathways in England: An ethnographic study.Journal of health services research & policy · 2025Article
- Malignant tumor cells engender second membrane-lined organelles for self-protection and tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit.British journal of cancer · 2024Article
- Nomenclature of the symptoms of head and neck cancer: a systematic scoping review.Frontiers in oncology · 2024Article
- What causes delays in diagnosing blood cancers? A rapid review of the evidence.Primary health care research & development · 2023Review
- Time intervals in the care pathway to cancer diagnosis during the COVID-19 pandemic: A large retrospective study from a high-volume center.International journal of cancer · 2023Article
- Developing and Validating a Lung Cancer Risk Prediction Model: A Nationwide Population-Based Study.Cancers · 2023Article
- Patient and tumour characteristics of screening-age adults diagnosed with screen-detected versus symptomatic colon cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Targeted Photodynamic Diagnosis and Therapy for Esophageal Cancer: Potential Role of Functionalized Nanomedicine.Pharmaceutics · 2021Review
- Rapid Diagnostic Centres and early cancer diagnosis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
- Impact of the Presenting Symptom on Time Intervals and Diagnostic Routes of Patients with Symptomatic Oral Cancer.Cancers · 2021Article
- Women's barriers for contacting general practice when experiencing gynecological cancer symptoms: a population-based study.BMC family practice · 2021Article
- Exploring primary care level provider interpretation and management of potential breast and cervical cancer signs and symptoms in South Africa.Ecancermedicalscience · 2021Article
- Evaluation of salivary protein patterns among a rural population exposed and non-exposed to arsenic-contaminated drinking water in areas of Tucumán (Argentina): a pilot study.Journal of applied oral science : revista FOB · 2021Article
Corrections and comments
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Authors and funding
10 authors at 9 institutions in 6 countries.
Funding
Abstract
Diagnosing cancer earlier can enable timely treatment and optimize outcomes. Worldwide, national cancer control plans increasingly encompass early diagnosis programs for symptomatic patients, commonly comprising awareness campaigns to encourage prompt help-seeking for possible cancer symptoms and health system policies to support prompt diagnostic assessment and access to treatment. By their nature, early diagnosis programs involve complex public health interventions aiming to address unmet health needs by acting on patient, clinical, and system factors. However, there is uncertainty regarding how to optimize the design and evaluation of such interventions. We propose that decisions about early diagnosis programs should consider four interrelated components: first, the conduct of a needs assessment (based on cancer-site-specific statistics) to identify the cancers that may benefit most from early diagnosis in the target population; second, the consideration of symptom epidemiology to inform prioritization within an intervention; third, the identification of factors influencing prompt help-seeking at individual and system level to support the design and evaluation of interventions; and finally, the evaluation of factors influencing the health systems' capacity to promptly assess patients. This conceptual framework can be used by public health researchers and policy makers to identify the greatest evidence gaps and guide the design and evaluation of local early diagnosis programs as part of broader cancer control strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.