ArticleCirculation2021
Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells.
Abstract readLetter
In one paragraph
Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Clinical assessment of endothelial function in convalescent COVID-19 patients: a meta-analysis with meta-regressions.Annals of medicine · 2022Pooled it
- Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysis.Thrombosis research · 2022Pooled it
- COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells.Seminars in immunopathology · 2022Pooled it
- Use of novel antithrombotic agents for COVID-19: Systematic summary of ongoing randomized controlled trials.Journal of thrombosis and haemostasis : JTH · 2021Pooled it
- sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial.Scientific reports · 2025Trial
- The effect of TRV027 on coagulation in COVID-19: A pilot randomized, placebo-controlled trial.British journal of clinical pharmacology · 2023Trial
- T1R3 Anchors ACE2 at the Pulmonary Endothelial Cell Surface to Attenuate Vascular Injury Following SARS-CoV-2 Spike 1 Protein Exposure In Vitro.Journal of cellular and molecular medicine · 2026Article
- Differential effects of SARS-CoV-2-targeted infection of ATII, club cells, and macrophages on lung immunopathology and antiviral responses.Mucosal immunology · 2026Article
- DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction.Journal of nanobiotechnology · 2026Article
- Nature versus nurture: genetic background and media composition shape endothelial cell transcriptomes in vitro.Scientific reports · 2026Article
- Neuroinflammation and Oxidative Stress in Parkinson's Disease, Alzheimer's Disease, and COVID-19: Microglia-Neutrophil Interaction.ACS omega · 2026Review
- Resistance of endothelial cells to SARS-CoV-2 infectionJournal of virology · 2025Article
- Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19.Journal of virology · 2025Article
- CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling.Acta pharmacologica Sinica · 2025Article
- Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells.Inflammation · 2025Article
- Selective Inhibition of Vascular Smooth Muscle Cell Function by COVID-19 Antiviral Drugs: Impact of Heme Oxygenase-1.Antioxidants (Basel, Switzerland) · 2025Article
- Vasoprotective effects of lysophosphatidic acid inhibit vascular injury caused by SARS-CoV-2 infection.Scientific reports · 2025Article
- CXCL10-dependent epithelial-vascular cross-talk for endothelial activation following SARS-CoV-2 infection.Scientific reports · 2025Article
- SARS-CoV-2 infection promotes lung thrombosis by inducing integrinβ3 expression in vascular endothelial cells.Scientific reports · 2025Article
- Endothelial growth media components alter SARS-CoV-2 spike-directed growth kinetics.Journal of virological methods · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Ian R McCrackenCentre for Cardiovascular Science (I.R.M., A.H.B.), University of Edinburgh, Little France Crescent, United Kingdom.
Gaye SagincNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Liqun HeDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (L.H., M.A.-M., C.B.).
Alik HuseynovNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Alison Daniels *Infection Medicine (A.D., S.J.G., J.G.H.), University of Edinburgh, Little France Crescent, United Kingdom.
Sarah Fletcher *The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom (S.F., N.M.C., C.T.-B.).
Claire PeghaireNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Viktoria KalnaNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Maarja Andaloussi-MäeDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (L.H., M.A.-M., C.B.).
Lars MuhlIntegrated Cardio Metabolic Centre (L.M., U.L., C.B.), Karolinska Institute, Sweden.
Nicky M CraigThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom (S.F., N.M.C., C.T.-B.).
Samantha J GriffithsInfection Medicine (A.D., S.J.G., J.G.H.), University of Edinburgh, Little France Crescent, United Kingdom.
Jürgen G HaasInfection Medicine (A.D., S.J.G., J.G.H.), University of Edinburgh, Little France Crescent, United Kingdom.
Christine Tait-BurkardThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom (S.F., N.M.C., C.T.-B.).
Urban LendahlIntegrated Cardio Metabolic Centre (L.M., U.L., C.B.), Karolinska Institute, Sweden.
Graeme M BirdseyNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Christer BetsholtzDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (L.H., M.A.-M., C.B.).
Michela NosedaNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Andrew H BakerCentre for Cardiovascular Science (I.R.M., A.H.B.), University of Edinburgh, Little France Crescent, United Kingdom.
Anna M RandiNational Heart and Lung Institute, National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, United Kingdom (G.S., A.H., C.P., V.K., G.M.B., M.N., A.M.R.).
Funding
British Heart Foundation CH/11/2/28733British Heart Foundation RG/11/17/29256British Heart Foundation RG/17/4/32662British Heart Foundation SP/19/1/34461
Abstract
PubMed holds no abstract for this paper.
Indexed as
Virus ReplicationAngiotensin-Converting Enzyme 2Endothelial CellsHumansSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2angiotensin-converting enzyme 2COVID-19endothelial cellsendothelial injurySARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.