Evidence map›Paper›PMID 33405741›Full record

ArticleACS biomaterials science & engineering2019

Improving Sensitivity and Specificity of Amyloid-β Peptides and Tau Protein Detection with Antibiofouling Magnetic Nanoparticles for Liquid Biopsy of Alzheimer's Disease.

Yuancheng Li, Esther Lim, Travis Fields, Hui Wu, Yaolin Xu, Y Andrew Wang, Hui Mao

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuancheng LiDepartment of Radiology and Imaging Sciences, Emory University, 1841 Clifton Road NE, Atlanta, Georgia 30329, United States.
Esther LimDivision of Research, Philadelphia College of Osteopathic Medicine-Georgia Campus, 625 Old Peachtree Road NW, Suwanee, Georgia 30039, United States.
Travis FieldsDivision of Research, Philadelphia College of Osteopathic Medicine-Georgia Campus, 625 Old Peachtree Road NW, Suwanee, Georgia 30039, United States.
Hui WuDepartment of Radiology and Imaging Sciences, Emory University, 1841 Clifton Road NE, Atlanta, Georgia 30329, United States.
Yaolin XuDepartment of Radiology and Imaging Sciences, Emory University, 1841 Clifton Road NE, Atlanta, Georgia 30329, United States.
Y Andrew WangOcean Nanotech, LLC, 7964 Arjons Drive, San Diego, California 92126, United States of America.
Hui MaoDepartment of Radiology and Imaging Sciences, Emory University, 1841 Clifton Road NE, Atlanta, Georgia 30329, United States.ORCID http://orcid.org/0000-0002-0147-6022
Emory University · USPhiladelphia College of Osteopathic Medicine · USOcean NanoTech (United States) · US

Funding

Stroma Breaking Theranostic Nanoparticle for Targeted Pancreatic Cancer TherapyU01CA198913 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2015 to 2019
$3.0M
Targeted therapy of peritoneal carcinomatosis using theranostic nanoparticlesR01CA202846 · NCI · EMORY UNIVERSITY · PI MAO, HUI, WANG, YONGQIANG ANDREW · 2016 to 2020
$2.4M
MRI Capable Receptor Targeted Drug Delivery for Pancreatic CancerR01CA154846 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2011 to 2015
$2.1M
NCI NIH HHS R01 CA154846NCI NIH HHS R01 CA202846NCI NIH HHS U01 CA198913
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a growing global healthcare burden affecting the aging population and society. Given the lack of effective treatment to AD, early detection at the prodromal stage and timely monitoring of changes during progression are considered the best approach to control and intervene in disease progression. "Liquid biopsy" of AD biomarkers amyloid-β peptides (Aβs) and tau proteins in the cerebrospinal fluid (CSF) or blood samples holds great promises for cost-effective, widely accessible, and easy-administrated noninvasive detection and follow-up of AD. However, current

Indexed as

Alzheimer’s diseaseamyloid-β peptidesbiofoulingimmunomagnetic separationmagnetic nanoparticlestau proteins

Identifiers

PMID33405741
PMCPMC8720568
OpenAlexW2946990960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.