Evidence map›Paper›PMID 33405335›Full record

ArticleChemistry, an Asian journal2020

Improved Antiproliferative Activity and Fluorescence of a Dinuclear Gold(I) Bisimidazolylidene Complex via Anthracene-Modification.

Christian H G Jakob, Bruno Dominelli, Jonas F Schlagintweit, Pauline J Fischer, Franziska Schuderer, Robert M Reich, Fernanda Marques, João D G Correia, Fritz E Kühn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Evaluation of the Anticancer Effects ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian H G JakobDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
Bruno DominelliDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
Jonas F SchlagintweitDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
Pauline J FischerDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
Franziska SchudererDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
Robert M ReichDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
Fernanda MarquesCentro de Ciências e Tecnologias Nucleares and Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional N° 10 (km 139,7), 2695-066, Bobadela LRS, Portugal.
João D G CorreiaCentro de Ciências e Tecnologias Nucleares and Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional N° 10 (km 139,7), 2695-066, Bobadela LRS, Portugal.
Fritz E KühnDepartment of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.ORCID http://orcid.org/0000-0002-4156-780X

Funding

Fundação para a Ciência e Tecnologia, Portugal PTDC/QUI-NUC/30147/2017Fundação para a Ciência e Tecnologia, Portugal UID/Multi/04349/2019TUM Graduate School
6 · The paper itself

Abstract

A straightforward modification route to obtain mono- and di-substituted anthroyl ester bridge functionalized dinuclear Au(I) bis-N-heterocyclic carbene complexes is presented. The functionalization can be achieved starting from a hydroxyl-functionalized ligand precursor followed by transmetallation of the corresponding Ag complex or via esterification of the hydroxyl-functionalized gold complex. The compounds are characterized by NMR-spectroscopy, ESI-MS, elemental analysis and SC-XRD. The mono-ester Au complex shows quantum yields around 18%. In contrast, the corresponding syn-di-ester Au complex, exhibits significantly lower quantum yields of around 8%. Due to insufficient water solubility of the di-ester, only the mono-ester complex has been tested regarding its antiproliferative activity against HeLa- (cervix) and MCF-7- (breast) cancer cell lines and a healthy fibroblast cell line (V79). IC

Indexed as

AnthracenesCell LineCell ProliferationCoordination ComplexesGoldHeLa CellsHumansImidazolidinesMCF-7 CellsMethaneMolecular ConformationSpectrophotometry, UltravioletAnthracenesbisimidazolylidenecarbeneCoordination ComplexesGoldImidazolidinesMethaneanticancerGoldluminescenceN-heterocyclic carbenetheranostic

Identifiers

PMID33405335
PMCPMC7756789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.