ArticleThe Laryngoscope2021
Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.
Open access · bronzeAbstract readConsensus Statement
In one paragraph
Article in The Laryngoscope, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Outcomes After Human Papillomavirus Vaccination in Patients With Recurrent Respiratory Papillomatosis: A Nonrandomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2022Trial
- Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP.The Laryngoscope · 2026Article
- Patient Perspectives on Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis.Laryngoscope investigative otolaryngology · 2026Article
- Comparison of COBioengineering (Basel, Switzerland) · 2026Article
- Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis.BMC medicine · 2026Article
- DNA Immunotherapy (INO-3107) Results in Long-Term Surgery Reduction in RRP.The Laryngoscope · 2025Observational
- Clinical Efficacy and Safety of Intralesional Bevacizumab in Dermatology: Insights from a Systematic Review.Dermatology practical & conceptual · 2025Review
- Chinese guideline for the diagnosis and treatment of juvenile-onset recurrent respiratory papillomatosis (2024).World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Off-label drugs in laryngology- what should the doctor and the patient know about such therapies? A consensus statement of the European Laryngological Society.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Chinese guideline for the diagnosis and treatment of juvenile-onset recurrent respiratory papillomatosis (2024).Pediatric investigation · 2025Article
- Profiling of VEGF Receptors and Immune Checkpoints in Recurrent Respiratory Papillomatosis.The Laryngoscope · 2024Article
- Systemic bevacizumab for treatment of recurrent respiratory papillomatosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Renal Implications of Long-Term Systemic Bevacizumab for Recurrent Respiratory Papillomatosis.The Annals of otology, rhinology, and laryngology · 2024Article
- Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023Review
- Systemic bevacizumab for pediatric patients with aggressive recurrent respiratory papillomatosis: One single-center experience of eight patients.Laryngoscope investigative otolaryngology · 2023Article
- [Recurrent laryngeal papillomatosis].HNO · 2023Review
- Systemic Use of Bevacizumab for Recurrent Respiratory Papillomatosis: Who, What, Where, When, and Why?The Laryngoscope · 2023Article
- Use of cryotherapy to treat obstructing papilloma of an accessory tracheal bronchus: case report.Journal of cardiothoracic surgery · 2022Article
- Systemic Bevacizumab for Severe Recurrent Respiratory Papillomatosis.Case reports in oncological medicine · 2022Article
- Application of Bevacizumab Combined With Chemotherapy in Patients With Colorectal Cancer and Its Effects on Brain-Gut Peptides, Intestinal Flora, and Oxidative Stress.Frontiers in surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors at 20 institutions in 13 countries.
Douglas R SidellDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.ORCID 0000-0002-5352-7469
Karthik BalakrishnanDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.ORCID 0000-0002-0244-249X
Simon R BestDepartment of Otolaryngology-Head and Neck Surgery, Division of Laryngology, and, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0001-8699-033X
Karen ZurDivision of Pediatric Otolaryngology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.ORCID 0000-0002-9045-6559
Julia BuckinghamMaternal and Child Health Research Institute, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford University, Stanford, California, U.S.A.
Alessandro De AlarconDepartment of Otolaryngology, Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.ORCID 0000-0003-4792-4676
Fuad M BaroodySection of Otolaryngology-Head and Neck Surgery and Department of Pediatrics, University of Chicago Medicine and The Comer Children's Hospital, Chicago, Illinois, U.S.A.
Jonathan M BockDepartment of Otolaryngology and Communication Sciences, Division of Laryngology and Professional Voice, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.ORCID 0000-0002-4367-7527
Emily F BossDepartment of Otolaryngology-Head and Neck Surgery and the Department of Health Policy and Management, Division of Pediatric Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.
Charles M BowerDepartment of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Arkansas for Medical Sciences (UAMS), Arkansas Children's Hospital, Little Rock, Alaska, U.S.A.
Paolo CampisiDepartment of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Canada.ORCID 0000-0002-2750-8117
Sharon F ChenDepartment of Pediatrics, Division of Infectious Diseases, Lucile Packard Children's Hospital Stanford, Stanford, California, U.S.A.
Jeffrey M ClarkeDepartment of Medicine, Division of Oncology, Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, U.S.A.
Kevin D ClarkePediatric Otolaryngology, Division of Otolaryngology Head and Neck Surgery, University of British Columbia (UBC, UVIc), Victoria General Hospital, Victoria, British Columbia, Canada.
Alejandro CocciagliaENT-Respiratory Endoscopy Department, Garrahan Children's Hospital, Buenos Aires, Argentina.
Robin T CottonDepartment of Otolaryngology, Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.
Giselle CuestasRespiratory Endoscopy Section, ENT Department, Hospital General de Niños "Dr. Pedro de Elizalde", Buenos Aires, Argentina.
Kara L DavisDepartment of Pediatrics, Division of Pediatric Oncology, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, California, U.S.A.
Victor H DeFagoPediatric Surgery, Sanatorio del Salvador Privado SA, Cordoba, Argentina.
Frederik G DikkersDepartment of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Ines DossansOtolaryngology-Head and Neck Surgery, Hospital Pereira Rossell, Montevideo, Uruguay.
Walter FlorezDepartment of Otolaryngology, Instituto Nacional de Salud del Niño de San Borja, Lima, Peru.
Elizabeth FoxComprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.
Aaron D FriedmanDepartment of Otolaryngology, Head and Neck Surgery, University of Cincinnati School of Medicine, Cincinnati, Ohio, U.S.A.ORCID 0000-0001-5615-3442
Nazaneen GrantDepartment of Otolaryngology, Division of Laryngology, Medstar Georgetown University Hospital, Georgetown, Washington, District of Columbia, U.S.A.
Osama HamdiHoward University College of Medicine, Washington, District of Columbia, U.S.A.ORCID 0000-0002-3495-9231
Norman D HogikyanDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.
Kaalan JohnsonUniversity of Washington School of Medicine, Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, Seattle, Washington, District of Columbia, U.S.A.
Liane B JohnsonDepartment of Surgery, Dalhousie University, Division of Paediatric Otolaryngology-Head and Neck Surgery, IWK Health Centre, Halifax, Nova Scotia, Canada.
Romaine F JohnsonDepartment of Otolaryngology-Head and Neck Surgery, University of Texas (UT) Southwestern Medical Center, Dallas, Texas, U.S.A.ORCID 0000-0002-2322-5347
Peggy KellyDepartment of Otolaryngology, Head and Neck Surgery, Division of Pediatric Otolaryngology, Children's Hospital Colorado affiliated with University of Colorado, Anschutz, Aurora, Colorado, U.S.A.
Adam M KleinDepartment of Otolaryngology-Head and Neck Surgery, Division of Laryngology, Emory Voice Center, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
Claire M LawlorDepartment of Otolaryngology, Division of Pediatric Otolaryngology, Children's National Health System, George Washington University School of Medicine, Washington, District of Columbia, U.S.A.
Nicolas LeboulangerHead and Neck Surgery, Pediatric Otolaryngology, Necker Enfants Malades Hospital, Paris University, Paris, France.ORCID 0000-0003-3466-6903
Alejandro G LevyDepartment of Pediatrics, Division of Pediatric Hematology and Oncology, Arnold Palmer Hospital Center for Children's Cancer and Blood Disorders, Orlando Health, Orlando, Florida, U.S.A.
Derek LamDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.
Greg R LicameliDepartment of Otolaryngology, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
Steve LongDepartment of Head and Neck Surgery, Kaiser Permanente, Hillsboro, Oregon, U.S.A.
David G LottDepartment of Otorhinolaryngology, Division of Laryngology, Mayo Clinic Arizona, Phoenix, Arizona, U.S.A.
Dayse ManriqueDepartment of Otorhinolaryngology, Universidad Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
James Scott McMurrayPediatric Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
Kara D MeisterDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.ORCID 0000-0002-4983-3068
Anna H MessnerDepartment of Otolaryngology/Head and Neck Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, U.S.A.
Michael MohrDepartment of Hematology, Oncology and Respiratory Medicine, University Hospital Muenster, Muenster, Germany.
Pamela MuddDepartment of Otolaryngology, Division of Pediatric Otolaryngology, Children's National Health System, George Washington University School of Medicine, Washington, District of Columbia, U.S.A.
Anthony J MortellitiDepartment of Otolaryngology-Head and Neck Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, U.S.A.
Daniel NovakovicDepartment of Otolaryngology, Head and Neck Surgery, Central Clinical School, Faculty of Medicine and Health, University of Sydney, The Canterbury Hospital, Sydney, New South Wales, Australia.ORCID 0000-0003-3839-1353
Julian OngkasuwanDepartment of Otolaryngology, Division of Adult and Pediatric Laryngology, Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, U.S.A.ORCID 0000-0001-8621-5456
Shazia PeerDivision of Otorhinolaryngology, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Krysztof PiersialaDivision of Ear, Nose and Throat Diseases, Karolinska Institutet, Karolinksa University Hospital, Stockholm, Sweden.
Jeremy D PragerDepartment of Otolaryngology, Head and Neck Surgery, Division of Pediatric Otolaryngology, Children's Hospital Colorado affiliated with University of Colorado, Anschutz, Aurora, Colorado, U.S.A.ORCID 0000-0002-8123-2529
Seth M PranskyRady Children's Hospital, San Diego, California, U.S.A.
Diego PreciadoDepartment of Otolaryngology, Division of Pediatric Otolaryngology, Children's National Health System, George Washington University School of Medicine, Washington, District of Columbia, U.S.A.
Tiffany RaynorDepartment of Otolaryngology, Head and Neck Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, U.S.A.
Rico N P M RinkelDepartment of Otolaryngology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.ORCID 0000-0003-0056-7827
Hugo RodriguezRespiratory Endoscopy Department, Hospital de Pediatria Prof Dr. Juan P. Garrahan, Buenos Aires, Argentina.
Verónica P RodríguezRespiratory Endoscopy Section, ENT Department, Hospital General de Niños "Dr. Pedro de Elizalde", Buenos Aires, Argentina.
John RussellDepartment of Paediatric Otolaryngology, Children's Health Ireland, Dublin, Ireland.
María Laura ScatoliniRespiratory Endoscopy Department, Hospital de Pediatria Prof Dr. Juan P. Garrahan, Buenos Aires, Argentina.
Patrick SchefflerDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, U.S.A.
David F SmithDivisions of Pediatric Otolaryngology, Pulmonary Medicine, and the Sleep Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A.ORCID 0000-0002-0048-4012
Lee P SmithDivision of Otolaryngology-Head and Neck Surgery, Pediatric Otolaryngology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, U.S.A.
Marshall E SmithDivision of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, U.S.A.
Richard J H SmithDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
Abraham SoromOtolaryngology, Head and Neck Surgery, Confluence Health, Wenatchee, Washington, District of Columbia, U.S.A.
Amalia SteinbergOtolaryngology, Head and Neck Surgery, Alaska Native Medical center, Anchorage, Alaska, U.S.A.
John A StithDepartment of Otolaryngology-Head and Neck Surgery, Division of Pediatric Otolaryngology, SSM Cardinal Glennon Children's Hospital Medical Center, St. Louis, Missouri, U.S.A.
Dana ThompsonDivision of Pediatric Otolaryngology Head and Neck Surgery Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, U.S.A.
Jerome W ThompsonDepartment of Otolaryngology-Head and Neck Surgery, Division of Pediatric ENT, LeBonheur Children's Hospital, College of Medicine, University of Tennnessee, Memphis, Tennessee, U.S.A.
Patricio VarelaPediatric Surgery Department, Universidad de Chile, Mackenna Children Hospital, Clinica Las Condes Medical center, Santiago, Chile.
David R WhiteDivision of Pediatric Otolaryngology, Medical University of South Carolina (MUSC) Shawn Jenkins Children's Hospital, Charleston, South Carolina, U.S.A.
Andre M WinelandDepartment of Otolaryngology-Head and Neck Surgery and the Department of Health Policy and Management, Division of Pediatric Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.ORCID 0000-0002-1576-3380
Christina J YangDepartment of Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Children's Hospital at Montefiore, New York, New York, U.S.A.
Carlton J ZdanskiDepartment of Otolaryngology/Head and Neck Surgery, Division of Pediatric Otolaryngology/Head and Neck Surgery, North Carolina Children's Hospital, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
Craig S DerkayDepartment of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Children's Hospital of the King's Daughters, Norfolk, Virginia, U.S.A.
Lucile Packard Children's Hospital · USChildren's National · USCincinnati Children's Hospital Medical Center · USGarrahan Hospital · ARJohns Hopkins University · USTexas Children's Hospital · USAmsterdam University Medical Centers · NLChildren's Hospital Colorado · USHospital Pedro de Elizalde · ARAlaska Native Medical Center · USArkansas Children's Hospital · USArnold Palmer Hospital for Children · USBoston Children's Hospital · USCardinal Glennon Children’s Medical Center · USCentro Hospitalario Pereira Rossell · UYChildren's Health Ireland at Crumlin · IEChildren's Hospital at Montefiore · USChildren's Hospital of Philadelphia · USChildren's Hospital of The King's Daughters · USClínica Las Condes · CL
Funding
Circadian Clock Dysregulation in a Model of Obstructive Sleep ApneaK08HL148551 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SMITH, DAVID F · 2019 to 2023
$818kNHLBI NIH HHS K08 HL148551
Abstract
objectives/hypothesisThe purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality. STUDY
designDelphi method-based survey series.
methodsA multidisciplinary, multi-institutional panel of physicians with experience using systemic bevacizumab for the treatment of RRP was established. The Delphi method was used to identify and obtain consensus on characteristics associated with systemic bevacizumab use across five domains: 1) patient characteristics; 2) disease characteristics; 3) treating center characteristics; 4) prior treatment characteristics; and 5) prior work-up.
resultsThe international panel was composed of 70 experts from 12 countries, representing pediatric and adult otolaryngology, hematology/oncology, infectious diseases, pediatric surgery, family medicine, and epidemiology. A total of 189 items were identified, of which consensus was achieved on Patient Characteristics (9), Disease Characteristics (10), Treatment Center Characteristics (22), and Prior Workup Characteristics (18).
conclusionThis consensus statement provides a useful starting point for clinicians and centers hoping to offer systemic bevacizumab for RRP and may serve as a framework to assess the components of practices and centers currently using this therapy. We hope to provide a strategy to offer the treatment and also to provide a springboard for bevacizumab's use in combination with other RRP treatment protocols. Standardized delivery systems may facilitate research efforts and provide dosing regimens to help shape best-practice applications of systemic bevacizumab for patients with early-onset or less-severe disease phenotypes. LEVEL OF EVIDENCE: 5 Laryngoscope, 131:E1941-E1949, 2021.
Indexed as
Angiogenesis InhibitorsBevacizumabConsensusDelphi TechniqueHumansInternationalityPapillomavirus InfectionsRespiratory Tract InfectionsAngiogenesis InhibitorsBevacizumabAvastinconsensusSystemic bevacizumab
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.