ArticleThe British journal of dermatology2021
Cellulitis in chronic oedema of the lower leg: an international cross-sectional study.
Article in The British journal of dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Prevalence, characteristics and risk factors for chronic lower-limb oedema in the older population living in the community or in an aged-care home: a systematic review.Age and ageing · 2026Pooled it
- A Systematic Review of Cellulitis Guidelines: The Role of Non-Pharmacological Management in Preventing Recurrence.The Australasian journal of dermatology · 2025Pooled it
- Exercise and cancer-related lymphedema in the lower limbs-a randomized cross-over trial on high-intensity interval training (HIIT) with and without compression garments.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Compression Therapy Is Cost-Saving in the Prevention of Lower Limb Recurrent Cellulitis in Patients with Chronic Edema.Lymphatic research and biology · 2023Trial
- Sustained benefit of compression therapy for preventing recurrent leg cellulitis: extended follow-up of a randomised controlled trial.EClinicalMedicine · 2026Article
- The impact of obesity on chronic oedema/lymphoedema of the leg - an international multicenter cross-sectional study (LIMPRINT).International journal of obesity (2005) · 2024Article
- Demonstrating the benefit of a cellulitis-specific patient reported outcome measure (CELLUPROMJournal of patient-reported outcomes · 2024Article
- Diagnosis and Treatments of Limb Lymphedema: Review.Annals of vascular diseases · 2024Review
- Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection-Sepsis Relationship.Diagnostics (Basel, Switzerland) · 2024Article
- Factors associated with cellulitis in lymphoedema of the arm - an international cross-sectional study (LIMPRINT).BMC infectious diseases · 2024Article
- Evaluating the cost of managing patients with cellulitis in Wales, UK: A 20-year population-scale study.International wound journal · 2023Article
- The Lymphatic System, Lymphoedema, and Medical Curricula-Survey of Australian Medical Graduates.Cancers · 2022Article
- Compression stockings for recurrent cellulitis.Canadian family physician Medecin de famille canadien · 2022Article
- Wounds in chronic leg oedema.International wound journal · 2022Article
- Recurrent Cellulitis: Who is at Risk and How Effective is Antibiotic Prophylaxis?International journal of general medicine · 2022Review
- Cellulitis in chronic oedema.The British journal of dermatology · 2021Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundCellulitis and chronic oedema are common conditions with considerable morbidity. The number of studies designed to assess the epidemiology of cellulitis in chronic oedema is scarce.
objectivesTo investigate the prevalence and risk factors of cellulitis in chronic leg oedema, including lymphoedema.
methodsA cross-sectional study included 40 sites in nine countries during 2014-17. Adults with clinically proven unilateral or bilateral chronic oedema (oedema > 3 months) of the lower leg were included. The main outcome measures were frequency and risk factors for cellulitis within the last 12 months.
resultsOut of 7477 patients, 15·78% had cellulitis within the last 12 months, with a lifetime prevalence of 37·47%. The following risk factors for cellulitis were identified by multivariable analysis: wounds [odds ratio (OR) 2·37, 95% confidence interval (CI) 2·03-2·78], morbid obesity (OR 1·51, 95% CI 1·27-1·80), obesity (OR 1·21, 95% CI 1·03-1·41), midline swelling (OR 1·32, 95% CI 1·04-1·66), male sex (OR 1·32, 95% CI 1·15-1·52) and diabetes (OR 1·27, 95% CI 1·08-1·49). Controlled swelling was associated with a reduced risk (OR 0·59, 95% CI 0·51-0·67). In a subgroup analysis, the risk increased with the stage of oedema [International Society of Lymphology, stage II OR 2·04 (95% CI 1·23-3·38) and stage III OR 4·88 (95% CI 2·77-8·56)].
conclusionsCellulitis in chronic leg oedema is a global problem. Several risk factors for cellulitis were identified, of which some are potentially preventable. Our findings suggest that oedema control is one of these. We also identified that advanced stages of oedema, with hard/fibrotic tissue, might be an important clinical indicator to identify patients at particular risk.
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