ReviewMolecular neurobiology2021
Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates.
Review in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06797804 (Effectiveness of Information Technology-Assisted Horticultural Therapy Program on Heart Rate Variability, Stress, Depression and Happiness Among Older Adults Resident in Long-Term Care Facilities), which is not on this map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Information Technology-Assisted Horticultural Therapy Program on Heart Rate Variability, Stress, Depression and Happiness Among Older Adults Resident in Long-Term Care Facilities
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 264 citations in OpenAlex.
- Factors Associated with Depression and Anxiety in Adults ≥60 Years Old during the COVID-19 Pandemic: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Exploring the COVID-19 pandemic's impact on mood, anxiety, and neurocognitive disorders in older adults: sex, geographic context, and healthcare setting considerations.Social psychiatry and psychiatric epidemiology · 2026Article
- The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults.Frontiers in psychiatry · 2026Article
- Impact of chronic comorbidities on psychological and social status in COVID-19 patients.Frontiers in psychology · 2026Article
- Article
- Temporal depressive symptom networks in older adults during the COVID-19 pandemic.Journal of mood and anxiety disorders · 2025Article
- The impact of the COVID-19 pandemic on the global burden of mental disorders: a counterfactual modeling study from 1990 to 2021.Translational psychiatry · 2025Article
- Associations Between Social Media Use and Anxiety and Depression Among Older Adults : Cross-Sectional Study.JMIR aging · 2025Article
- Developing a Prediction Model for Suicidality Among COVID-19 Patients in Korea Using Timely Data From the National Center for Disaster and Trauma.Journal of Korean medical science · 2025Article
- Dual inflammation in schizophrenia infected with COVID-19: Impact on cognitive function.Brain, behavior, & immunity - health · 2025Article
- Exploring Interindividual Variability in Resilience to Stress: Social Support, Coping Styles, and Diurnal Cortisol in Older Adults.Behavioral sciences (Basel, Switzerland) · 2025Article
- Factors Associated with Loneliness and Psychological Distress in Older Adults During the COVID-19 Pandemic in Kazakhstan: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Identification and Validation of Potential Biomarkers and Therapeutic Targets of COVID-19-related Depression.Combinatorial chemistry & high throughput screening · 2025Article
- Investigation and analysis of mental health status of the older adult in western rural areas.Frontiers in public health · 2025Article
- Can advancing environmental justice safeguard older adults' health? - Evidence from China's establishment of environmental courts.Frontiers in public health · 2025Article
- Melatonin's Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective.Journal of molecular neuroscience : MN · 2024Review
- Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis.Biogerontology · 2024Review
- The economic and psychological impacts of covid-19: a exploratory study of the intersection of traditional and new vulnerable groups in South Korea.BMC public health · 2024Article
- The Role of Inflammation in Depression and Beyond: A Primer for Clinicians.Current psychiatry reports · 2024Review
- The influence of widowhood and social engagement on cognitive impairment among Chinese older adults and factors mediating their association.Journal of global health · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since December 2019, the world has been experiencing the challenge of facing coronavirus disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS-CoV-2. The individuals with the most severe symptoms and the highest risk of death are the elderly and those with chronic illness. Among chronic conditions, those with a certain degree of chronic inflammation may predispose to a more severe evolution of COVID-19. Elderly with psychiatric disorders can present a persistent inflammatory state, a characteristic of the age's immunological senescence, but the disorder can accentuate that. Social isolation is still the safest way to avoid contamination. However, isolated older people may have or worsen mental health conditions due to isolation and health concerns. In this scenario, a SARS-CoV-2 infection may progress to more severe disease. Conversely, COVID-19 can predispose or aggravate psychiatric disorders, as it induces a cytokine storm, causing systemic hyper inflammation. It may damage the blood-brain barrier, resulting in inflammation in the central nervous system. Besides, SARS-CoV-2 is likely to reach and trigger an inflammatory process directly in the nervous system. This review makes an update about research on the mental health of the elderly during the pandemic. Also, it discusses the vulnerability of these individuals in the face of stress and in the case of contracting COVID-19, considering mainly the stress's hormonal and inflammatory mechanisms. Finally, the review points out possible care and attention strategies and entertainment and activities that can reduce the damage to mental and physical health and improve the elderly's quality of life. Graphical abstract Isolation and concerns about COVID-19 may harm elderly mental health. Immunosenescence and pandemic stress increase the risk of psychiatric disorders. Stress and disorders may potentiate the elderly's inflammation and COVID-19 symptoms. SARS-CoV-2 hyperinflammation is a risk factor for elderly psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.