Evidence map›Paper›PMID 33404860›Full record

ReviewCancer metastasis reviews2021

Macrophages in multiple myeloma: key roles and therapeutic strategies.

Khatora S Opperman, Kate Vandyke, Peter J Psaltis, Jacqueline E Noll, Andrew C W Zannettino

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Khatora S OppermanMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.ORCID https://orcid.org/0000-0001-6064-5044
Kate VandykeMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.ORCID https://orcid.org/0000-0002-1033-849X
Peter J PsaltisVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Jacqueline E NollMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia. jacqueline.noll@adelaide.edu.au.ORCID https://orcid.org/0000-0001-7375-635X
Andrew C W ZannettinoMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.ORCID https://orcid.org/0000-0002-6646-6167
South Australian Health and Medical Research Institute · AU

Funding

Endothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedR00HL102056 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LIN, MIKE T · 2012 to 2014
$686k
Endothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedK99HL102056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LIN, MIKE T · 2010 to 2011
$194k
6 · The paper itself

Abstract

Macrophages are a vital component of the tumour microenvironment and crucial mediators of tumour progression. In the last decade, significant strides have been made in understanding the crucial functional roles played by macrophages in the development of the plasma cell (PC) malignancy, multiple myeloma (MM). Whilst the interaction between MM PC and stromal cells within the bone marrow (BM) microenvironment has been extensively studied, we are only just starting to appreciate the multifaceted roles played by macrophages in disease progression. Accumulating evidence demonstrates that macrophage infiltration is associated with poor overall survival in MM. Indeed, macrophages influence numerous pathways critical for the initiation and progression of MM, including homing of malignant cells to BM, tumour cell growth and survival, drug resistance, angiogenesis and immune suppression. As such, therapeutic strategies aimed at targeting macrophages within the BM niche have promise in the clinical setting. This review will discuss the functions elicited by macrophages throughout different stages of MM and provide a comprehensive evaluation of potential macrophage-targeted therapies.

Indexed as

Multiple MyelomaBone MarrowHumansMacrophagesNeovascularization, PathologicTumor MicroenvironmentMacrophagesMicroenvironmentMultiple myelomaTherapeutics

Identifiers

PMID33404860
OpenAlexW3119873108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.