Trial reportNeuroradiology2021
Changes in brain functional connectivity and cognition related to white matter lesion burden in hypertensive patients from SPRINT.
Trial report in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systolic Blood Pressure Intervention Trial
Who cites it
9 citing papers in PubMed.
- Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.AJNR. American journal of neuroradiology · 2023Trial
- Neuroendocrine-vascular interaction is associated with thalamocortical disorganization and cognitive decline in perimenopausal hypertension.Frontiers in medicine · 2026Article
- Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging.JAMA network open · 2025Article
- Hypertension is associated with reduced resting-state medial temporal lobe dynamic network flexibility in older African Americans.Physiological reports · 2024Article
- Short-term blood pressure variability and brain functional network connectivity in older adults.Neuroimage. Reports · 2024Article
- Characterization of Resting-State Functional Connectivity Changes in Hypertension by a Modified Difference Degree Test.Brain connectivity · 2023Article
- Effects of hypertension and aging on brain function in spontaneously hypertensive rats: a longitudinal resting-state functional magnetic resonance imaging study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
purposeHypertension is a risk factor for cognitive impairment; however, the mechanisms leading to cognitive changes remain unclear. In this cross-sectional study, we evaluate the impact of white matter lesion (WML) burden on brain functional connectivity (FC) and cognition in a large cohort of hypertensive patients from the Systolic Blood Pressure Intervention Trial (SPRINT) at baseline.
methodsFunctional networks were identified from baseline resting state functional MRI scans of 660 SPRINT participants using independent component analysis. WML volumes were calculated from structural MRI. Correlation analyses were carried out between mean FC of each functional network and global WML as well as WML within atlas-defined white matter regions. For networks of interest, voxel-wise-adjusted correlation analyses between FC and regional WML volume were performed. Multiple variable linear regression models were built for cognitive test performance as a function of network FC, followed by mediation analysis.
resultsMean FC of the default mode network (DMN) was negatively correlated with global WML volume, and regional WML volume within the precuneus. Voxel-wise correlation analyses revealed that regional WML was negatively correlated with FC of the DMN's left lateral temporal region. FC in this region of the DMN was positively correlated to performance on the Montreal Cognitive Assessment and demonstrated significant mediation effects. Additional networks also demonstrated global and regional WML correlations; however, they did not demonstrate an association with cognition.
conclusionIn hypertensive patients, greater WML volume is associated with lower FC of the DMN, which in turn is related to poorer cognitive test performance.
trial registrationNCT01206062.
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