Evidence map›Paper›PMID 33404758›Full record

Trial reportClinical oral investigations2021

The consumption of milk supplemented with probiotics decreases the occurrence of caries and the salivary concentration of hβD-3 in children.

Francisca Sandoval, Simone Faleiros, Rodrigo Cabello, Mario Díaz-Dosque, Gonzalo Rodríguez, Alejandro Escobar

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Effects of Oral Probiotics onDentistry journal · 2026
    Review
  6. Article
  7. Review
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  12. Article
  13. Article
  14. Article
  15. [Research Progress in the Relationship BetweenSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Review
  16. Review
  17. Anti-caries Streptococcus spp.: A potential preventive tool for special needs patients.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Francisca SandovalDepartment of Restorative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile.
Simone FaleirosDepartment of Restorative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile.
Rodrigo CabelloDepartment of Restorative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile.
Mario Díaz-DosqueInstitute of Research in Dental Sciences, Dentistry Faculty, University of Chile, Olivos 943, 8380492, Santiago, Metropolitan Region, Chile.
Gonzalo RodríguezDepartment of Restorative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile.
Alejandro EscobarInstitute of Research in Dental Sciences, Dentistry Faculty, University of Chile, Olivos 943, 8380492, Santiago, Metropolitan Region, Chile. a.escobar@odontologia.uchile.cl.ORCID http://orcid.org/0000-0002-1587-4179
University of Chile · CLUniversity Ucinf · CL

Funding

Dirección de Investigación, Facultad de Odontología 17/011
6 · The paper itself

Abstract

objectivesThis study evaluated the effect of milk supplemented with Lactobacillus rhamnosus SP1 on the occurrence of caries and the salivary concentration of human β-defensin-3 (hβD-3) in preschool children with high caries risk. MATERIALS AND

methodsA sample of 42 children was randomly assigned to two groups; children in the intervention group were given 150 mL of milk supplemented with 10

resultsThere was an increase in the number of teeth with carious lesions (d

conclusionsThese findings showed that regular intake of probiotic-supplemented milk in preschool children with high caries risk decreased the occurrence of caries and the salivary levels of hβD-3. CLINICAL RELEVANCE: Our results suggest the need for developing and implementing probiotic supplementation, as adjuvants to the conventional treatments for caries and allow to considerate the salivary levels of hβD-3 as markers of oral tissue homeostasis.

Indexed as

beta-DefensinsDental CariesProbioticsAnimalsChild, PreschoolDental Caries SusceptibilityDietary SupplementsHumansMilkSalivaStreptococcus mutansbeta-DefensinsCaries preventionChildrenHuman beta-defensin-3Lactobacillus rhamnosus SP1Supplemented milk

Identifiers

PMID33404758
OpenAlexW3118722886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.