ArticleAnalytical and bioanalytical chemistry2021
Development and validation of a selective SPR aptasensor for the detection of anticancer drug irinotecan in human plasma samples.
Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Advanced Biosensing Strategies for Last-Line Antibiotics Vancomycin, Colistin, Daptomycin and Meropenem: Comparative Analysis of Electrochemical and Optical Detection Methods.Antibiotics (Basel, Switzerland) · 2026Article
- Picomolar-Level Sensing of Cannabidiol by Metal Nanoparticles Functionalized with Chemically Induced Dimerization Binders.ACS sensors · 2023Article
- A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip.Heliyon · 2023Article
- Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring.Analytical chemistry · 2022Article
- Lanthanide (EuInternational journal of molecular sciences · 2022Article
- Analytical Considerations of Large-Scale Aptamer-Based Datasets for Translational Applications.Cancers · 2022Review
- SARS-CoV-2 Aptasensors Based on Electrochemical Impedance Spectroscopy and Low-Cost Gold Electrode Substrates.Analytical chemistry · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In this work, a surface plasmon resonance (SPR)-based assay for the quantification of antineoplastic drug irinotecan in human plasma samples has been developed for the first time. The selective binding of irinotecan with an aptamer receptor, operating in human plasma, allowed to set-up a novel analytical methodology to detect the drug in the analytical range of interest by using SPR as detection technique. After hybridizing the aptamer to the sensing platform and optimizing the sample preparation procedure, a quantitative assay was validated according to FDA regulatory guidelines. The analytical working range was found between 100 and 7500 ng mL
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