ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021
Early- and long-term surgical outcomes in 109 children with lipomyelomeningocele.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 22 citations in OpenAlex.
- Microsurgical Untethering of Pediatric Lipomyelomeningocele: A Stepwise, Photo-Illustrated Technical Note.Brain sciences · 2026Article
- Closed spinal dysraphism: Think about it in the case of enuresis in children.Radiology case reports · 2025Article
- Delayed Diagnosis of Lumbosacral Lipomyelomeningocele With Tethered Cord: A Case Report.Cureus · 2025Article
- Clinical impact of fetal sac size on closed neural tube defects.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Lipomyelomeningocele in a Newborn: A Case Report.Cureus · 2025Article
- Influencing Factors on Independent Walking in Children With Lumbosacral Lipomas: A Retrospective Cohort Study Based on a 5-Year Untethering Series.Clinical medicine insights. Pediatrics · 2024Article
- Surgery for spina bifida occulta: spinal lipoma and tethered spinal cord.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Risk factors for pre-operative functional deterioration in children with lipomyelomeningocele.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Feasibility and diagnostic accuracy of intra-operative monitoring of motor evoked potentials in children <2 years of age undergoing tethered cord surgery: results in 100 children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
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4 authors at 1 institution in 1 country.
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Abstract
aimTo determine the functional outcomes and risk factors for outcomes following surgery for lipomyelomeningocele (LMMC).
methodsData from 109 children with LMMC who underwent surgery from January 2008 to December 2017 were retrospectively studied to evaluate functional outcomes and possible risk factors for early- (at discharge from hospital or within 1 month of surgery) and long-term outcomes after surgery.
resultsThere were 53 boys and 56 girls with median age of 36 months (IQR 12-90 months; range, 4 months to 18 years) at surgery. At presentation, neurological function was normal (asymptomatic group) in 28 (25.7%) children while there was neurological dysfunction (symptomatic group) in 81 (74.3%). Near total or radical excision of lipoma was done in 71 (65.1%) children. Six (5.8%) children had deterioration of neurological function in the post-operative period with recovery of function in three of them. There were no statistically significant risk factors for early outcomes. At a mean follow-up of 62.5 months (IQR 35-82 months; range, 12-146 months), 21 (27.6%) of the 76 symptomatic group children (including 59.3% with incomplete bladder dysfunction) showed improvement, 52 (68.4%) remained the same, while 3 (4%) deteriorated. In 31 children (symptomatic group) who developed symptoms after 1 year of age, early surgery after development of symptoms was associated with better chances of recovery (p = 0.0008). In the asymptomatic group, 23 (88.5%) had normal neurological function at mean follow-up of 57.5 months (IQR 30-77 months; range, 12-141 months) and 3 (11.5%) had neurological deterioration. The mean time to late deterioration (re-tethering) from surgery was 51.3 months (IQR 24-75 months; range, 24-84 months). Presence of syrinx on initial MRI (p = 0.008) and partial resection of the lipoma (p = 0.02) were independent risk factors for delayed deterioration.
conclusionRadical resection of LMMC probably helps in preserving neurological function in > 90% of children at long-term follow-up. Fifty-five percent of children > 2 years of age with incomplete bladder dysfunction regained normal function following surgery. In children who develop symptoms after birth, early surgical intervention can reverse the neurological deficits.
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