Evidence map›Paper›PMID 33404712›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Patterns of care for pediatric patients with newly-diagnosed grade II gliomas.

Nicolette Taku, Kristina D Woodhouse, Kai-Ping Liao, Chidinma P Anakwenze, Rebecca A Harrison, Wafik Zaky, Arnold C Paulino, Debra N Yeboa

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Nicolette TakuDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ntaku@mdanderson.org.ORCID http://orcid.org/0000-0003-2710-9404
Kristina D WoodhouseDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kai-Ping LiaoDepartment of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chidinma P AnakwenzeDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rebecca A HarrisonDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wafik ZakyDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Arnold C PaulinoDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Debra N YeboaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe describe large-scale demographic, initial treatment, and outcomes data for pediatric grade II gliomas included in the National Cancer Database from 2004 to 2014.

methodsOur cohort included cases less than 21 years of age with pathology-confirmed disease. Logistic regressions were used to evaluate the use of chemotherapy (CT) and radiation therapy (RT). Overall survival (OS) rates were determined using Kaplan-Meier estimates and the log-rank test.

resultsWe identified 803 cases with astrocytoma (56.2%), oligodendroglioma (26.0%), and mixed glioma/glioma NOS (17.8%) histologies. Most cases underwent surgical resection (n = 661). Whereas cases 16 to 21 years of age were more likely than cases 0 to 5 years to receive RT (OR = 7.38, 95% CI 3.58-15.21, p < 0.001), they were less likely to receive CT (OR = 0.34, 95% CI 0.22-0.52, p < 0.001). The 5-year OS rates for all cases, cases that underwent surgical resection, and cases managed with biopsy were 87.5%, 92.7%, and 63.6%, respectively.

conclusionIn one of the largest series of pediatric grade II gliomas, astrocytoma was the most common histology. Patterns of care and OS outcomes were similar to grade I gliomas, with surgical resection being the most common initial treatment and associated with a favorable rate of OS. Younger patients were more likely to receive post-operative CT and the use of RT increased with age.

Indexed as

AstrocytomaBrain NeoplasmsGliomaOligodendrogliomaAdultChildChild, PreschoolHumansInfantInfant, NewbornKaplan-Meier EstimateBrain tumorsGliomasGrade IIPediatrics

Identifiers

PMID33404712

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.