ReviewPlant communications2020
Engineering Plant Cytochrome P450s for Enhanced Synthesis of Natural Products: Past Achievements and Future Perspectives.
Review in Plant communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Evaluation of AlphaFold3 for Predicting Human Heme-Binding Protein Structures.International journal of molecular sciences · 2026Article
- Engineering of plant-derived P450scc forSynthetic and systems biotechnology · 2026Article
- Subcellular localization of enzymes involved in the biosynthesis of digoxin inFrontiers in plant science · 2026Article
- Protein design drives synthetic biology research of plant natural products.Biodesign research · 2025Review
- De novo biosynthesis of Asperosaponin VI inSynthetic and systems biotechnology · 2025Article
- Enhanced chlorogenic acid production from glucose via systematic metabolic engineering ofSynthetic and systems biotechnology · 2025Article
- Engineering the cytochrome P450 to enhance parthenolide production inSynthetic and systems biotechnology · 2025Article
- Recent trends in the elucidation of complex triterpene biosynthetic pathways in horticultural trees.Horticulture research · 2025Article
- Systematic Engineering ofJournal of fungi (Basel, Switzerland) · 2024Article
- Reconstitution of early paclitaxel biosynthetic network.Nature communications · 2024Article
- AtMYBS1 negatively regulates heat tolerance by directly repressing the expression of MAX1 required for strigolactone biosynthesis in Arabidopsis.Plant communications · 2023Article
- Searching for protein variants with desired properties using deep generative models.BMC bioinformatics · 2023Article
- Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity.Frontiers in plant science · 2023Review
- Metabolic engineering of Rhodotorula toruloides for resveratrol production.Microbial cell factories · 2022Article
- Engineering medicinal plant-derived CYPs: a promising strategy for production of high-valued secondary metabolites.Planta · 2022Review
- Metabolic engineering of Yarrowia lipolytica for scutellarin production.Synthetic and systems biotechnology · 2022Article
- De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories.Nature communications · 2021Article
- Article
- Enhanced chemoselectivity of a plant cytochrome P450 through protein engineering of surface and catalytic residues.aBIOTECH · 2021Article
- Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome P450s (P450s) are the most versatile catalysts and are widely used by plants to synthesize a vast array of structurally diverse specialized metabolites that not only play essential ecological roles but also constitute a valuable resource for the development of new drugs. To accelerate the metabolic engineering of these high-value metabolites, it is imperative to identify and characterize pathway P450s, and to further improve their activities through protein engineering. In this review, we focus on P450 engineering and summarize the major strategies for enhancing the stability and activity of P450s and successful cases of P450 engineering. Studies in which the functions of P450s were altered to create
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.