Evidence map›Paper›PMID 33404503›Full record

ArticleeLife2021

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression.

Aynur Kaya-Çopur, Fabio Marchiano, Marco Y Hein, Daniel Alpern, Julie Russeil, Nuno Miguel Luis, Matthias Mann, Bart Deplancke, Bianca H Habermann, Frank Schnorrer

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  19. PK1 fromOpen biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aynur Kaya-ÇopurAix Marseille University, CNRS, IBDM, Turing Center for Living Systems, Marseille, France.ORCID 0000-0002-3161-9442
Fabio MarchianoAix Marseille University, CNRS, IBDM, Turing Center for Living Systems, Marseille, France.
Marco Y HeinMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-9490-2261
Daniel AlpernInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Julie RusseilInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Nuno Miguel LuisAix Marseille University, CNRS, IBDM, Turing Center for Living Systems, Marseille, France.ORCID 0000-0001-5438-9638
Matthias MannMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0003-1292-4799
Bart DeplanckeInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0001-9935-843X
Bianca H HabermannAix Marseille University, CNRS, IBDM, Turing Center for Living Systems, Marseille, France.ORCID 0000-0002-2457-7504
Frank SchnorrerAix Marseille University, CNRS, IBDM, Turing Center for Living Systems, Marseille, France.ORCID 0000-0002-9518-7263

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated with growth of the contractile apparatus is not understood. Here, we use the large

Indexed as

Gene Expression RegulationAnimalsDrosophila melanogasterHippo Signaling PathwayMuscle Fibers, SkeletalMyofibrilsSarcomeresdevelopmental biologyD. melanogasterDrosophilaHippomusclemyofibrilsarcomereyorkie

Identifiers

PMID33404503
PMCPMC7815313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.