Evidence map›Paper›PMID 33404278›Full record

ArticleAutophagy2021

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone

Jun-Yi Zhu, Shabab B Hannan, Nina M Dräger, Natalia Vereshchagina, Ann-Christin Krahl, Yulong Fu, Christopher J H Elliott, Zhe Han, Thomas R Jahn, Tobias M Rasse

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Cells · 2025
    Article
  4. Article
  5. Advances in the study of autophagy in breast cancer.Breast cancer (Tokyo, Japan) · 2024
    Review
  6. Roles of α-Synuclein and Disease-Associated Factors inInternational journal of molecular sciences · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jun-Yi ZhuResearch Group Synaptic Plasticity, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Shabab B HannanResearch Group Synaptic Plasticity, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Nina M DrägerSchaller Research Group at the University of Heidelberg and DKFZ, Proteostasis in Neurodegenerative Disease (B180), German Cancer Research Center, Heidelberg, Germany.
Natalia VereshchaginaResearch Group Synaptic Plasticity, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Ann-Christin KrahlResearch Group Synaptic Plasticity, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Yulong FuCenter for Genetic Medicine Research, Children's National Medical Center, Washington, DC USA.
Christopher J H ElliottDepartment of Biology, University of York, York, UK.
Zhe HanCenter for Genetic Medicine Research, Children's National Medical Center, Washington, DC USA.
Thomas R JahnSchaller Research Group at the University of Heidelberg and DKFZ, Proteostasis in Neurodegenerative Disease (B180), German Cancer Research Center, Heidelberg, Germany.
Tobias M RasseResearch Group Synaptic Plasticity, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-4090-7662
German Cancer Research Center · DEChildren's National · USHertie Institute for Clinical Brain Research · DEUniversity of York · GB

Funding

Modeling Nephrotic Syndrome in Drosophila NephrocytesR01DK098410 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI HAN, ZHE · 2014 to 2022
$3.3M
Integrating Drosophila and human podocyte studies to discover APOL1 renal toxicity mechanism and therapeutic targetsR01DK120908 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI HAN, ZHE · 2019 to 2022
$1.4M
NIDDK NIH HHS R01 DK098410NIDDK NIH HHS R01 DK120908Parkinson's UK H-1201Parkinson's UK K-1704
6 · The paper itself

Abstract

We investigated in larval and adult

Indexed as

DrosophilaDrosophila ProteinsAnimalsAutophagyAutophagy-Related Protein 7Autophagy-Related ProteinsHydrogen PeroxideNerve Tissue ProteinsNeuromuscular JunctionProtein Deglycase DJ-1Protein Serine-Threonine KinasesPTEN-Induced Putative KinaseAtg101 protein, DrosophilaAtg7 protein, DrosophilaAutophagy-Related Protein 7Autophagy-Related ProteinsDJ-1beta protein, DrosophilaDrosophila ProteinsHydrogen PeroxideLRRK protein, DrosophilaNerve Tissue ProteinsPINK1 protein, DrosophilaProtein Deglycase DJ-1Protein Serine-Threonine KinasesPTEN-Induced Putative KinaseAtg1Hsc70-5microtubulemitochondriamitophagyrapamycinsynapse

Identifiers

PMID33404278
PMCPMC8526020
OpenAlexW3119331849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.