Evidence map›Paper›PMID 33404004›Full record

Trial reportSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde2020

Substance use and depressive and anxiety symptoms among out-of-school adolescent girls and young women in Cape Town, South Africa.

C P Bonner, T Carney, F A Browne, J W Ndirangu, B N Howard, W M Wechsberg

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02974998 (Expanding HIV Testing and Prevention to Reach Vulnerable Young Women), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02974998 nacompletednot on this map

Expanding HIV Testing and Prevention to Reach Vulnerable Young Women

TypeinterventionalSponsorRTI InternationalRan2016 to 2019Enrolled500ConditionsCondomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug UseArmsYoung Women's Health CoOp (YWHC), Standard HTC
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

C P BonnerSubstance Use, Gender, and Applied Research Program, RTI International, Atlanta, GA, USA. cpbonner@rti.org.
T Carney
F A Browne
J W Ndirangu
B N Howard
W M Wechsberg
RTI International · USNorth Carolina Division of Public Health · USSouth African Medical Research Council · ZA

Funding

Expanding HIV Testing and Prevention to Reach Vulnerable Young WomenR01DA041227 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI WECHSBERG, WENDEE M · 2015 to 2019
$2.0M
NIDA NIH HHS R01 DA041227
6 · The paper itself

Abstract

backgroundThere is a high prevalence of substance use among youth in South Africa (SA), and adolescent girls and young women (AGYW) experience high rates of depression and anxiety. Substance use behaviours and mental health are associated with other public health problems among AGYW such as HIV and unintended pregnancy. Therefore, understanding the relationship between substance use and mental health is imperative to improve AGYW's health.

objectivesTo examine the association between heavy drinking, marijuana, methamphetamine and methaqualone (Mandrax) use and depressive and anxiety symptoms among AGYW aged 16 - 19 years who have dropped out of school in Cape Town, SA.

methodsData for this report come from the baseline data of 500 participants of an ongoing cluster-randomised trial assessing the efficacy of a young woman-focused intervention to reduce substance use and HIV risk. After AGYW consented/assented to participate, they completed a urine drug screen and a baseline questionnaire.

resultsLogistic and negative binomial regressions, controlling for clustering at the neighbourhood level, revealed that frequency of depressive symptoms was significantly and positively related to a positive drug screen for Mandrax (β=0.07; p=0.03). All other associations between the frequency of depressive symptoms and substance use were not statistically significant (ps>0.05). The associations between frequency of anxiety symptoms and substance use were not statistically significant (ps>0.05).

conclusionsOur findings highlight the need to address substance use, especially Mandrax use and its associated risk, and depression in an integrated, youth-friendly setting.

Indexed as

AdolescentAlcohol DrinkingAnxietyDepressionFemaleHIV InfectionsHumansMental HealthPrevalenceSouth AfricaSubstance Abuse DetectionSubstance-Related DisordersSurveys and QuestionnairesYoung Adult

Identifiers

PMID33404004
PMCPMC10729586
OpenAlexW3113005854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.