ArticleAnnals of clinical and translational neurology2021
Initial findings in traumatic peripheral nerve injury and repair with diffusion tensor imaging.
Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Meta-analysis of the normal diffusion tensor imaging values of the median nerve and how they change in carpal tunnel syndrome.Scientific reports · 2021Pooled it
- Diffusion MRI as A Biomarker for Monitoring Recovery After Surgical Repair of Traumatic Peripheral Nerve Injuries: A Longitudinal Case Series.Research square · 2026Article
- Quantitative study and prognostic value of diffusion tensor imaging for lumbar spinal stenosis.BMC medical imaging · 2026Article
- Modeling Postoperative Nerve Regeneration Using Diffusion MRI: A Preclinical Study of a Novel Mathematical Approach.Muscle & nerve · 2026Article
- Diffusion tractography outside the brain: the road less travelled.Brain structure & function · 2026Review
- Clinical Anatomy and Diagnostic Challenges in Peripheral Nerve Trauma for the Forensic Physician.Diagnostics (Basel, Switzerland) · 2025Review
- Combination of morphological and multiparametric MR neurography enhances carpal tunnel syndrome diagnosis and evaluation.Scientific reports · 2025Article
- Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve.Neurology international · 2024Article
- Advances in Imaging of Compressive Neuropathies.Hand clinics · 2024Review
- Multiparametric Quantitative MRI of Peripheral Nerves in the Leg: A Reliability Study.Journal of magnetic resonance imaging : JMRI · 2024Article
- Improved visualization of median, ulnar nerves, and small branches in the wrist and palm using contrast-enhanced magnetic resonance neurography.Therapeutic advances in neurological disorders · 2024Article
- Updates in peripheral nerve surgery of the upper extremity: diagnosis and treatment options.Annals of translational medicine · 2023Review
- Correlation between diffusion tensor indices and fascicular morphometric parameters of peripheral nerve.Frontiers in physiology · 2023Article
- Magnetic resonance tractography of the brachial plexus: step-by-step.Quantitative imaging in medicine and surgery · 2022Article
- Article
- Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve.Journal of clinical medicine · 2022Article
- Automatic detection of abnormal hand gestures in patients with radial, ulnar, or median nerve injury using hand pose estimation.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveManagement of peripheral nerve injuries requires physicians to rely on qualitative measures from patient history, electromyography, and physical exam. Determining a successful nerve repair can take months to years for proximal injuries, and the resulting delays in clinical decision-making can lead to a negative impact on patient outcomes. Early identification of a failed nerve repair could prevent permanent muscle atrophy and loss of function. This study aims to test the feasibility of performing diffusion tensor imaging (DTI) to evaluate injury and recovery following repair of wrist trauma. We hypothesize that DTI provides a noninvasive and reliable assessment of regeneration, which may improve clinical decision-making and alter the clinical course of surgical interventions.
methodsClinical and MRI measurements from subjects with traumatic peripheral nerve injury, carpal tunnel syndrome, and healthy control subjects were compared to evaluate the relationship between DTI metrics and injury severity.
resultsFractional anisotropy from DTI was sensitive to differences between damaged and healthy nerves, damaged and compressed nerves, and injured and healthy contralateral nerves. Longitudinal measurements in two injury subjects also related to clinical outcomes. Implications of other diffusion measures are also discussed.
interpretationDTI is a sensitive tool for wrist nerve injuries and can be utilized for monitoring nerve recovery. Across three subjects with nerve injuries, this study has shown how DTI can detect abnormalities between injured and healthy nerves, measure recovery, and determine if re-operation was successful. Additional comparisons to carpal tunnel syndrome and healthy nerves show that DTI is sensitive to the degree of impairment.
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Registered trials
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