Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.
Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Behaviour change techniques used in interventions targeting dementia risk factors amongst older adults in rural and remote areas: A systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Attitudes and Preferences Towards Screening for Dementia From the Perspectives of Healthcare Professionals: An Updated Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- Umbrella review and Delphi study on modifiable factors for dementia risk reduction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Dietary changes following a lifestyle-based intervention for dementia risk reduction - results from the AgeWell.de study.European journal of nutrition · 2024Trial
- A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results.Alzheimer's research & therapy · 2024Trial
- Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial.Alzheimer's research & therapy · 2024Trial
- The Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) score as a predictor for cognitive decline and potential surrogate outcome in the FINGER lifestyle randomized controlled trial.European journal of neurology · 2024Trial
- Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Trial
- Co-Designing a Digital Brain Health Intervention for Chinese Older Adults: A User-Centred Approach.Australasian journal on ageing · 2026Article
- Associations of the Lifestyle for Brain Health (LIBRA) index with cognitive functioning across adulthood: Variation by sex and socioeconomic status in the German National Cohort (NAKO).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Socioeconomic differences in dementia risk, lifestyle, and relevant determinants of behavior.Journal of Alzheimer's disease : JAD · 2026Article
- Evaluating MRI correlates of lifestyle-based dementia risk reduction: Results from the AgeWell.de imaging study.Journal of Alzheimer's disease : JAD · 2026Article
- The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk.Alzheimer's research & therapy · 2026Article
- Psychosocial hierarchies of modifiable risk for Alzheimer's disease: A networks analysis.PloS one · 2026Article
- End User and Primary Care Physicians' Perspectives on Digital Innovations in Dementia Risk Detection: Focus on a Digital Sleep Biomarker.JMIR aging · 2025Article
- The LIBRA index of modifiable risk factors for mild cognitive impairment and dementia in a late-life population-based cohort study.AJE advances : research in epidemiology · 2025Article
- Lifestyle, genetic risk, plasma pTau217, and incident cognitive impairment in WRAP.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Multidomain interventions for prevention of dementia: Achievements, challenges and future perspectives.Geriatrics & gerontology international · 2025Review
- Lifestyle and cognition: Separating the effects of average lifestyle and lifestyle changes based on the LIBRA score.The journal of prevention of Alzheimer's disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIndividuals in early dementia prevention trials may differ in how much they benefit from interventions depending on their initial risk level. Additionally, modifiable dementia risk scores might be used as surrogate/intermediate outcomes.
methodsIn the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated in post hoc analyses (N = 1207) whether the cognitive benefits of the 2-year multi-domain lifestyle intervention differed by baseline dementia risk measured with the "LIfestyle for BRAin Health" (LIBRA) score. We also investigated intervention effects on change in LIBRA score over time.
resultsOverall, higher baseline LIBRA was related to less cognitive improvement over time. This association did not differ between the intervention and control groups. The intervention was effective in decreasing LIBRA scores over time, regardless of baseline demographics or cognition. DISCUSSION: The cognitive benefit of the FINGER intervention was similar across individuals with different LIBRA scores at baseline. Furthermore, LIBRA may be useful as a surrogate/intermediate endpoint and surveillance tool to monitor intervention success during trial execution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.