Evidence map›Paper›PMID 33403631›Full record

ArticleEnvironmental science and pollution research international2021

Protective effect of gamma-oryzanol against manganese-induced toxicity in Drosophila melanogaster.

Neicí Cáceres Silva, Márcia Rósula Poetini, Matheus Chimelo Bianchini, Francielli Polet Almeida, Mustafá Munir Mustafa Dahle, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Elize Aparecida Santos Musachio, Bruna Piaia Ramborger, Diogo La Rosa Novo and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Neicí Cáceres SilvaUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Márcia Rósula PoetiniUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Matheus Chimelo BianchiniUniversidade Federal do Pampa, Campus Uruguaiana, Programa de Pós-Graduação em Bioquímica (PPGBioq), BR-472 Km 7, Uruguaiana, RS, CEP 97500-970, Brazil.
Francielli Polet AlmeidaUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Mustafá Munir Mustafa DahleUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Stífani Machado AraujoUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Vandreza Cardoso BortolottoUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Elize Aparecida Santos MusachioUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil.
Bruna Piaia RamborgerUniversidade Federal do Pampa, Campus Uruguaiana, Programa de Pós-Graduação em Bioquímica (PPGBioq), BR-472 Km 7, Uruguaiana, RS, CEP 97500-970, Brazil.
Diogo La Rosa NovoUniversidade Federal de Pelotas, Campus Universitário, S/N - Prédio/Bloco: 30 e 32, Capão do Leão, RS, CEP 96160-000, Brazil.
Rafael RoehrsUniversidade Federal do Pampa, Campus Uruguaiana, Programa de Pós-Graduação em Bioquímica (PPGBioq), BR-472 Km 7, Uruguaiana, RS, CEP 97500-970, Brazil.
Marcia Foster MeskoUniversidade Federal de Pelotas, Campus Universitário, S/N - Prédio/Bloco: 30 e 32, Capão do Leão, RS, CEP 96160-000, Brazil.
Marina PrigolUniversidade Federal do Pampa (UNIPAMPA), Campus Itaqui, Programa de Pós-Graduação em Bioquímica (PPGBioq), Rua Joaquim de Sá Britto, s/n - Bairro Promorar, Itaqui, RS, CEP 97650-000, Brazil. marinaprigol@unipampa.com.br.
Robson Luiz PuntelUniversidade Federal do Pampa, Campus Uruguaiana, Programa de Pós-Graduação em Bioquímica (PPGBioq), BR-472 Km 7, Uruguaiana, RS, CEP 97500-970, Brazil. robsonpuntel@unipampa.edu.br.
Universidade Federal do Pampa · BRUniversidade Federal de Pelotas · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #16/2551-0000248-7Conselho Nacional de Desenvolvimento Científico e Tecnológico #301807/2018-3Conselho Nacional de Desenvolvimento Científico e Tecnológico #307099/2017-2Conselho Nacional de Desenvolvimento Científico e Tecnológico #449428/2014-1
6 · The paper itself

Abstract

Manganese (Mn) is an essential element that, in excess, seems to be involved in the development of different neurodegenerative conditions. Gamma-oryzanol (Ory) was previously reported to possess antioxidant and neuroprotective properties. Thus, we conducted this study to test the hypothesis that Ory can also protect flies in an Mn intoxication model. Adult wild-type flies were fed over 10 days with Mn (5 mM) and/or Ory (25 μM). Flies treated with Mn had a decrease in locomotor activity and a higher mortality rate compared to those in controls. Mn-treated flies also had a significant increase in acetylcholinesterase (AChE) activity, in Mn accumulation and in oxidative stress markers. Moreover, flies treated with Mn exhibited a significant decrease in dopamine levels and in tyrosine hydroxylase activity, as well as in mitochondrial and cellular viability. Particularly important, Ory protected against mortality and avoided locomotor and biochemical changes associated with Mn exposure. However, Ory did not prevent the accumulation of Mn. The present results support the notion that Ory effectively attenuates detrimental changes associated with Mn exposure in Drosophila melanogaster, reinforcing its neuroprotective action/potential.

Indexed as

Drosophila melanogasterManganeseAnimalsAntioxidantsOxidative StressPhenylpropionatesAntioxidantsgamma-oryzanolManganesePhenylpropionatesDopamineFliesManganismMn accumulationOxidative stress

Identifiers

PMID33403631
OpenAlexW3119682415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.