ArticleBrain topography2021
Chemotherapy-Induced Brain Effects in Small-Cell Lung Cancer Patients: A Multimodal MRI Study.
Article in Brain topography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A comparative analysis of serum and tissue proteomic profiles in non-small cell lung cancer patients with or without brain metastasis.Cell death discovery · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer.Frontiers in oncology · 2026Article
- Cognitive impairment and brain atrophy in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a normative analysis.Frontiers in neurology · 2025Article
- White matter microstructure damage measured by automated fiber quantification correlates with pain symptoms in lung cancer patients.Brain imaging and behavior · 2024Article
- Altered structural covariance of the cortex and hippocampal formation in patients with lung cancer after chemotherapy.Heliyon · 2024Article
- Uncovering brain functional connectivity disruption patterns of lung cancer-related pain.Brain imaging and behavior · 2024Article
- Article
- Association of Longitudinal Changes in Cerebral Microstructure with Cognitive Functioning in Breast Cancer Survivors after Adjuvant Chemotherapy.Journal of clinical medicine · 2024Article
- Effect of adding individualized health education for patients with brain metastasis of lung cancer undergoing radiotherapy, as measured by MRI and cognitive testing.American journal of translational research · 2024Article
- Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: a longitudinal multicenter data pooling analysis.Brain imaging and behavior · 2023Article
- Cognitive changes are associated with increased blood-brain barrier leakage in non-brain metastases lung cancer patients.Brain imaging and behavior · 2023Article
- Overview of methods and available tools used in complex brain disorders.Open research Europe · 2023Review
- A Comparative Analysis of White Matter Structural Networks on SCLC Patients After Chemotherapy.Brain topography · 2022Article
- Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer.Frontiers in neurology · 2022Article
- Altered Functional Connectivity in Pain-Related Brain Regions and Its Correlation with Pain Duration in Bone Metastasis with Cancer Pain.Disease markers · 2022Article
- Auxiliary Diagnosis of Lung Cancer with Magnetic Resonance Imaging Data under Deep Learning.Computational and mathematical methods in medicine · 2022Article
- Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy.Frontiers in molecular biosciences · 2022Article
- Expression of oncogenic long noncoding RNA PSMG3-antisense 1 in lung squamous cell carcinoma.Oncology letters · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The golden standard of treating Small Cell Lung Cancer (SCLC) entails application of platinum-based chemotherapy, is often accompanied by Prophylactic Cranial Irradiation (PCI), which have been linked to neurotoxic side-effects in cognitive functions. The related existing neuroimaging research mainly focuses on the effect of PCI treatment in life quality and expectancy, while little is known regarding the distinct adverse effects of chemotherapy. In this context, a multimodal MRI analysis based on structural and functional brain data is proposed in order to evaluate chemotherapy-specific effects on SCLC patients. Data from 20 patients (after chemotherapy and before PCI) and 14 healthy controls who underwent structural MRI, DTI and resting state fMRI were selected in this study. From a structural aspect, the proposed analysis included volumetry and thickness measurements on structural MRI data for assessing gray matter dissimilarities, as well as deterministic tractography and Tract-Based Spatial Statistics (TBSS) on DTI data, aiming to investigate potential white matter abnormalities. Functional data were also processed on the basis of connectivity analysis, evaluating brain network parameters to identify potential manifestation of functional inconsistencies. By comparing patients to healthy controls, the obtained results revealed statistically significant differences, with the patients' brains presenting reduced volumetry/thickness and fractional anisotropy values, accompanied by prominent differences in functional connectivity measurements. All above mentioned findings were observed in patients that underwent chemotherapy.
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