Evidence map›Paper›PMID 33403555›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2021

The incidence, risk, presentation, pathophysiology, treatment, and effects of perioperative acute kidney injury.

Frederic T Billings, Marcos G Lopez, Andrew D Shaw

Open access · bronzeAbstract read
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Frederic T BillingsDepartment of Anesthesiology, Vanderbilt University Medical Center, 1161 21st Avenue South, T-4202, MCN, Nashville, TN, 37232, USA. frederic.t.billings@vumc.org.ORCID http://orcid.org/0000-0001-7135-7785
Marcos G LopezDepartment of Anesthesiology, Vanderbilt University Medical Center, 1161 21st Avenue South, T-4202, MCN, Nashville, TN, 37232, USA.
Andrew D ShawDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB, Canada.
Vanderbilt University Medical Center · USUniversity of Alberta · CA

Funding

Hyper-oxygenation, oxidative stress, and kidney injury following cardiac surgeryR01GM112871 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BILLINGS, FREDERIC TREMAINE · 2015 to 2019
$1.8M
Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injuryK23GM102676 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BILLINGS, FREDERIC TREMAINE · 2012 to 2016
$808k
Perioperative Oxygenation, Endothelial Dysfunction, and Organ Injury in Cardiac SurgeryK23GM129662 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LOPEZ, MARCOS G · 2018 to 2022
$764k
NIGMS NIH HHS K23 GM102676NIGMS NIH HHS K23 GM129662NIGMS NIH HHS R01 GM112871NIH HHS K23GM102676NIH HHS K23GM129662NIH HHS R01GM112871
6 · The paper itself

Abstract

purposePresent clinical updates, current research findings, and consensus statements relevant to the care of the acute kidney injury (AKI) patient. PRINCIPAL

findingsAcute kidney injury is one of the most frequent and debilitating complications of surgery and critical illness. Consensus criteria use serum creatinine and urine output measurements to diagnose AKI and allow for objective diagnosis and more accurate comparisons across populations. New serum and urine biomarkers may provide earlier evidence of AKI, but their clinical utility, while increasing, remains limited. Avoidance of nephrotoxins, intravascular fluid management, and maintenance of renal perfusion are the mainstays of preventive management and treatment of AKI. Optimal timing for the initiation of renal replacement therapy is controversial and remains under investigation.

conclusionsAcute kidney injury continues to affect large numbers of patients receiving surgery or in the intensive care unit, but specific advances in resuscitation techniques, endpoint refinements, epidemiology, biomarkers, and pathology are providing the necessary framework to reduce AKI and associated morbidity.

Indexed as

Acute Kidney InjuryBiomarkersCreatinineHumansIncidenceIntensive Care UnitsRenal Replacement TherapyBiomarkersCreatinineacute kidney injuryAKIdialysisperioperativerenal failurerenal replacement therapysurgery

Identifiers

PMID33403555
PMCPMC8088760
OpenAlexW3120249407

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.