Evidence map›Paper›PMID 33403017›Full record

ArticleTherapeutic advances in medical oncology2020

Failure patterns and outcomes of dose escalation of stereotactic body radiotherapy for locally advanced pancreatic cancer: a multicenter cohort study.

Xiaofei Zhu, Yangsen Cao, Tingshi Su, Xixu Zhu, Xiaoping Ju, Xianzhi Zhao, Lingong Jiang, Yusheng Ye, Fei Cao, Shuiwang Qing and 1 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Stereotactic Body Radiation Therapy for Locally Advanced Pancreatic Cancer.Clinical and experimental gastroenterology · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. World journal of gastrointestinal oncology · 2021
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaofei ZhuDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.ORCID https://orcid.org/0000-0001-5769-9308
Yangsen CaoDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Tingshi SuDepartment of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Xixu ZhuDepartment of Radiation Oncology, General Hospital of Eastern Theater Command, Nanjing, Jiangsu, China.
Xiaoping JuDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Xianzhi ZhaoDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Lingong JiangDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Yusheng YeDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Fei CaoDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Shuiwang QingDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Huojun ZhangDepartment of Radiation Oncology, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Second Military Medical University · CNTumor Hospital of Guangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to compare recurrence patterns and outcomes of biologically effective dose (BED

methodsPatients from three centers with a biopsy and a radiographically proven LAPC were retrospectively included and data were prospectively collected from June 2012 to June 2019. Radiotherapy was delivered by stereotactic body radiation therapy. Recurrences were categorized as in-field, marginal, and outside-the-field recurrence. Patients in two groups were required to receive abdominal enhanced contrast CT or MRI every 2-3 months and CA19-9 examinations every month during follow-up. Treatment-related toxicities were evaluated every month. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method.

resultsAfter propensity score matching, there were 486 patients in each group. The median prescription dose of the two groups was 37 Gy/5-8 f (range: 36-40.8 Gy/5-8 f) and 42 Gy/5-8 f (range: 40-49.6 Gy/5-8 f), respectively. The median OS of patients with a BED

conclusionBED

Indexed as

dose escalationoutcomepancreatic cancerpatterns of failureradiotherapy

Identifiers

PMID33403017
PMCPMC7739203
OpenAlexW3112945554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.