Evidence map›Paper›PMID 33403013›Full record

ArticleTherapeutic advances in medical oncology2020

A deep-learning-based prognostic nomogram integrating microscopic digital pathology and macroscopic magnetic resonance images in nasopharyngeal carcinoma: a multi-cohort study.

Fan Zhang, Lian-Zhen Zhong, Xun Zhao, Di Dong, Ji-Jin Yao, Si-Yang Wang, Ye Liu, Ding Zhu, Yin Wang, Guo-Jie Wang and 5 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Fan ZhangDepartment of Head and Neck Oncology, The Cancer Center of the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Lian-Zhen ZhongSchool of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, P. R. China.
Xun ZhaoSchool of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, P. R. China.
Di DongSchool of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, P. R. China.
Ji-Jin YaoDepartment of Head and Neck Oncology, The Cancer Center of the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Si-Yang WangDepartment of Head and Neck Oncology, The Cancer Center of the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Ye LiuDepartment of Pathology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Ding ZhuDepartment of Pathology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Yin WangDepartment of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Guo-Jie WangDepartment of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Yi-Ming WangGuangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Dan LiGuangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, P. R. China.
Jiang WeiDepartment of Radiation Oncology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Province 541000, P. R. China.
Jie TianCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Hong ShanGuangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, P. R. China.
Fifth Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CNShandong Institute of Automation · CNUniversity of Chinese Academy of Sciences · CNGuilin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the prognostic value of radiomics-based and digital pathology-based imaging biomarkers from macroscopic magnetic resonance imaging (MRI) and microscopic whole-slide images for patients with nasopharyngeal carcinoma (NPC).

methodsWe recruited 220 NPC patients and divided them into training (

resultsBoth radiomic and histopathologic signatures presented significant associations with treatment failure in the three cohorts (C-index: 0.689-0.779, all

conclusionThe multi-scale imaging features showed a complementary value in prognostic prediction and may improve individualized treatment in NPC.

Indexed as

digital pathologymulti-scale featuresnasopharyngeal carcinomaradiomicssurvival analysis

Identifiers

PMID33403013
PMCPMC7739087
OpenAlexW3113127491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.