Evidence map›Paper›PMID 33402958›Full record

ArticleAfrican health sciences2020

Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa.

Lehlohonolo John Mathibe, Nonhle Perseverance Zwane

Open access · diamondAbstract read
In one paragraph

Article in African health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

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  5. The microbiome in mind: Reflections on antibiotic prescription in primary care.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
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  18. Twenty years ofAfrican health sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lehlohonolo John MathibeDivision of Pharmacology (Therapeutics), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, South Africa.
Nonhle Perseverance ZwaneAspen Pharmacare, Port Elizabeth, South Africa.
Port Elizabeth Provincial Hospital · ZAUniversity of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute upper respiratory tract infections (URTIs) are contagious diseases of the upper airways, but they are self-limiting in nature. Therefore, antimicrobial-use for the majority of the URTIs is considered inappropriate. Unfortunately, globally, antimicrobials are still being prescribed for the treatment of URTIs, especially in children. However, there is insufficient evidence on the causes of this phenomenon in South Africa.

objectiveTo investigate whether the parents/guardians accompanying children with URTIs expected/influenced physicians and/or nurses to prescribe antibiotics.

methodsThis was a prospective descriptive and explorative questionnaire-based study. Participants were guardians who accompanied children aged five years and below, diagnosed with acute URTIs.

findingsThree hundred and six parents/guardians participated in this study. Seventy six percent (n=233) of participants received antibiotics for URTIs for their children, and 67% (n=156) of these did not make requests for antimicrobial therapy. On overall, there was a statistically significant (p < 0.0001) chance (with OR of 5.9; 95% CI, 2.4 - 14.2) for receiving antibiotics for URTIs without a request.

conclusionPhysicians and other healthcare providers need education on rational prescribing of antimicrobials, and to implement evidence-based standard treatment guidelines, to reduce inappropriate use of antibiotics in children with self-limiting URTIs.

Indexed as

AdolescentAdultAnti-Bacterial AgentsChildChild, PreschoolCross-Sectional StudiesDrug PrescriptionsFemaleHumansInappropriate PrescribingMaleMiddle AgedParentsPhysician-Patient RelationsPractice Patterns, Physicians'Prospective StudiesAnti-Bacterial AgentsAntibioticsantimicrobialschildrenprescribingupper respiratory tract infections

Identifiers

PMID33402958
PMCPMC7751518
OpenAlexW3092280555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.