Evidence map›Paper›PMID 33402935›Full record

ArticleAfrican health sciences2020

Potential anti-proliferative effects of chemical constituents and hemisynthetic derivatives from

Annie Laure Ngankeu Pagning, Jean-de-Dieu Tamokou, Bushra Taj Muhammad, David Ngnokam, Leon AzefackTapondjou, Mohammad Shaiq Ali, Muhammad Waqar Hameed

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Annie Laure Ngankeu PagningResearch Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P O Box 183, Dschang, Cameroon.
Jean-de-Dieu TamokouResearch Unit of Microbiology and antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067 Dschang, Republic of Cameroon.
Bushra Taj MuhammadInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
David NgnokamResearch Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P O Box 183, Dschang, Cameroon.
Leon AzefackTapondjouResearch Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P O Box 183, Dschang, Cameroon.
Mohammad Shaiq AliInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Muhammad Waqar HameedInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
International Center for Chemical and Biological Sciences · PKUniversity of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiological significance of

objectiveCurrent study is focused to elaborate the anti-proliferative effects of natural isolates (compounds 1-6, 9) and hemi-synthetic analogs (compounds 7-8) extracted from

methodsColumn chromatography of the ethyl acetate extract followed by purification of different fractions led to the isolation of seven compounds (1 - 6, 9). Esterification reaction of compound 6 was carried out using butyroyl chlorides and triethylamin to produce two derivatives (7 - 8). The cytotoxic activity was performed after staining of treated cells with florescent dye propidium iodide. Dead cells were detected using cytometer FL2 or FL3 channels/filters.

resultsTrans-derivative of narciclasine (a natural isolate from

conclusionFrom our results, narciclasine appears to hold the potential of a lead molecule that can be used to bridge the therapeutic gaps in cancer research.

Indexed as

AmaryllidaceaeAntineoplastic AgentsCameroonCell ProliferationChromonesCytotoxinsHeterocyclic Compounds, 4 or More RingsHumansPlant Extracts7-deoxy-trans-dihydronarcistatinAntineoplastic AgentsChromonesCytotoxinsfarrerolHeterocyclic Compounds, 4 or More RingsPlant Extracts7-deoxy-trans-dihydronarciclasinAmaryllidaceaecytotoxic activityderivatizationfarrerolScadoxus pseudocaulus

Identifiers

PMID33402935
PMCPMC7750053
OpenAlexW3021711153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.