Evidence map›Paper›PMID 33402901›Full record

ArticleAfrican health sciences2020

High viral suppression and low attrition in healthy HIV-infected patients initiated on ART with CD4 above 500 cells/µL in a program setting in Uganda.

Dathan M Byonanebye, Fred C Semitala, Jackson Katende, Alex Bakenga, Irene Arinaitwe, Peter Kyambadde, Patrick Musinguzi, Irene Andia Biraro, Pauline Byakika-Kibwika, Moses R Kamya

Open access · diamondAbstract read
In one paragraph

Article in African health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dathan M ByonanebyeMakerere University College of Health Sciences, Kampala, Uganda.
Fred C SemitalaMakerere University College of Health Sciences, Kampala, Uganda.
Jackson KatendeMakerere University Joint AIDS Program, Kampala, Uganda.
Alex BakengaMakerere University College of Health Sciences, Kampala, Uganda.
Irene ArinaitweMakerere University College of Computing and Information Science.
Peter KyambaddeMost at Risk Populations Initiative, Kampala, Uganda.
Patrick MusinguziMulago National Referral and Teaching Hospital, Kampala, Uganda.
Irene Andia BiraroMakerere University College of Health Sciences, Kampala, Uganda.
Pauline Byakika-KibwikaMakerere University College of Health Sciences, Kampala, Uganda.
Moses R KamyaMakerere University College of Health Sciences, Kampala, Uganda.
Makerere University · UGAssociates Research · UGInfectious Diseases Research Collaboration · UGMulago Hospital · UG

Funding

Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in UgandaD43TW010037 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KAMYA, MOSES ROBERT, SEMITALA, FRED C · 2015 to 2025
$3.3M
FIC NIH HHS D43 TW010037
6 · The paper itself

Abstract

backgroundThe World Health Organization recommends antiretroviral therapy (ART) for all HIV-infected patients at all CD4 counts. However, there are concerns that asymptomatic patients may have poorer viral suppression and high attrition.

objectivesWe sought to determine attrition and viral suppression among healthy HIV-infected patients initiated on ART in program settings.

methodsThis cross-sectional study enrolled ART-experienced patients attending two PEPFAR-supported, high-volume clinics in Kampala, Uganda. Eligible patients were >18 years and had completed at least six months on ART. Participants were interviewed on socio-demographics, ART history and plasma viral load (VL) determined using Abbott Real-time. Predictors of viral suppression (<75 copies/ml) were determined using multivariate logistic regression.

resultsOverall, 267 participants were screened, 228 were eligible and 203 (89%) retained in care (visit within 90 days). Of the 203 participants, 115 (56.7%) were key-populations. Viral suppression was achieved in 173 patients (85%; 95% CI, 80.3%-90.1%). The factors associated with viral suppression were prior VL tests (AOR 6.98; p-value <0.001) and receiving care from a general clinic (AOR 5.41; p=0.009).

conclusionAsymptomatic patients initiated on ART with high baseline CD4 counts, achieve high viral suppression with low risk of attrition. VL monitoring and clinic type are associated with viral suppression.

Indexed as

AdultAmbulatory Care FacilitiesAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCross-Sectional StudiesDelivery of Health CareFemaleHIV InfectionsHumansMaleUgandaViral LoadAnti-HIV Agentsacquired immunodeficiency syndromeKey populationsviral load

Identifiers

PMID33402901
PMCPMC7750048
OpenAlexW3017786446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.