Evidence map›Paper›PMID 33402705›Full record

ArticleMolecular psychiatry2021

FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents.

Nitin Khandelwal, Sheridan Cavalier, Volodymyr Rybalchenko, Ashwinikumar Kulkarni, Ashley G Anderson, Genevieve Konopka, Jay R Gibson

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Structural and Functional Aspects of the Neurodevelopmental GeneFrontiers in molecular neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nitin KhandelwalDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0001-7229-4413
Sheridan Cavalier *Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0003-3494-1450
Volodymyr Rybalchenko *Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Ashwinikumar KulkarniDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Ashley G AndersonDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Genevieve KonopkaDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Genevieve.Konopka@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-3363-7302
Jay R GibsonDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Jay.Gibson@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-6279-0736
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

The role of Foxp1-regulated signaling pathways in brain development and behaviorR01MH102603 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE · 2015 to 2019
$2.2M
NIMH NIH HHS R01 MH102603
6 · The paper itself

Abstract

Heterozygous loss-of-function mutations in the transcription factor FOXP1 are strongly associated with autism. Dopamine receptor 2 expressing (D2) striatal projection neurons (SPNs) in heterozygous Foxp1 (Foxp1

Indexed as

Corpus StriatumPotassiumAnimalsForkhead Transcription FactorsMiceMice, Inbred C57BLNeuronsRepressor ProteinsTranscription FactorsForkhead Transcription FactorsFoxp1 protein, mousePotassiumRepressor ProteinsTranscription Factors

Identifiers

PMID33402705
PMCPMC8255328
OpenAlexW3118557228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.