ArticleCommunications biology2021
Controllability over stressor decreases responses in key threat-related brain areas.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- No changes in triple network engagement following (combined) noradrenergic and glucocorticoid stimulation in healthy men.Social cognitive and affective neuroscience · 2024Trial
- Reducing state anxiety with alpha-frequency transcranial alternating current stimulation.Research square · 2026Article
- Article
- Perceived control as a resilience factor: associations with neural, physiological and affective stress responses and mental health.Translational psychiatry · 2026Article
- Neural Bases of Affect-Based Impulsivity: A Decision Neuroscience Account.Computational psychiatry (Cambridge, Mass.) · 2026Review
- Controllability changes pain perception by increasing the precision of expectations.Nature communications · 2025Article
- White matter microstructural and macrostructural profiles during midlife reveal sex differences between men and women at different menopausal stages.Scientific reports · 2025Article
- Increasing resilience to stress by home-based transcranial stimulation.Research square · 2025Article
- Article
- The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.Communications biology · 2024Article
- Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety.Journal of affective disorders · 2024Article
- Sound suppresses earliest visual cortical processing after sight recovery in congenitally blind humans.Communications biology · 2024Article
- Neural response to monetary incentives in acquired adolescent depression after mild traumatic brain injury: Stage 2 Registered Report.Brain communications · 2024Article
- Anxiety associated with perceived uncontrollable stress enhances expectations of environmental volatility and impairs reward learning.Scientific reports · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Threat and Reward Imminence Processing in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Environmental change or choice during early rearing improves behavioural adaptability in laying hen chicks.Scientific reports · 2023Article
- Work stressors and their controllability: Content analysis of employee perceptions of hindrances to the flow of work in the health care sector.Current psychology (New Brunswick, N.J.) · 2023Article
- Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors.Molecular psychiatry · 2023Article
- Prediction and action in cortical pain processing.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on responses to stressors is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how controllability altered responses to a shock-plus-sound stressor with a between-group yoked design, where participants in controllable and uncontrollable groups experienced matched stressor exposure. Employing Bayesian multilevel analysis at the level of regions of interest and voxels in the insula, and standard voxelwise analysis, we found that controllability decreased stressor-related responses across threat-related regions, notably in the bed nucleus of the stria terminalis and anterior insula. Posterior cingulate cortex, posterior insula, and possibly medial frontal gyrus showed increased responses during control over stressor. Our findings support the idea that the aversiveness of stressors is reduced when controllable, leading to decreased responses across key regions involved in anxiety-related processing, even at the level of the extended amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.