Evidence map›Paper›PMID 33402685›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2021

Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation.

Jianqin Li, Yalin Xia, Xiaoru Fan, Xiaofang Wu, Feiyun Yang, Shaoyan Hu, Zhaoyue Wang

Erratum issuedOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  11. Immune Status and Chemokine C Receptor 7 Expression in Primary in Patients with Immune ThrombocytopeniaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2022
    Article
  12. Review
  13. The Extensive Regulation of MicroRNA in Immune Thrombocytopenia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jianqin LiHematology Department, The Children's Hospital of Soochow University, Suzhou, 215000, China. uxksew@163.com.ORCID 0000-0002-5744-9752
Yalin XiaHematology Department, The Children's Hospital of Soochow University, Suzhou, 215000, China.
Xiaoru FanHematology Department, The Children's Hospital of Soochow University, Suzhou, 215000, China.
Xiaofang WuHematology Department, The Children's Hospital of Soochow University, Suzhou, 215000, China.
Feiyun YangHematology Department, The Children's Hospital of Soochow University, Suzhou, 215000, China.
Shaoyan HuHematology Department, The Children's Hospital of Soochow University, Suzhou, 215000, China.
Zhaoyue WangThe First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, 215000, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abnormal differentiation of T helper 17 (Th17) cells is considered a vital promoter of immune thrombocytopenia (ITP) progression. Therefore, this study investigated the role of miR-199a-5p in Th17 differentiation and determined whether extracellular vesicles (EVs) derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells (ADSCs) could relieve ITP by inhibiting Th17 differentiation. The miR-199a-5p level was lessened in the spleen tissues of mice with ITP, while the signal transducer and activator of transcription 3 (STAT3) expression and the population of Th17 in CD4

Indexed as

Extracellular VesiclesMesenchymal Stem CellsTh17 CellsAdipose TissueAnimalsCell DifferentiationMaleMiceMice, Inbred BALB CMicroRNAsPurpura, Thrombocytopenic, IdiopathicMicroRNAsMirn199 microRNA, mouse

Identifiers

PMID33402685
OpenAlexW4206912658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.