ArticleNPJ microgravity2021
Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest.
Article in NPJ microgravity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04856410 (Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions (Spatial Cognition)
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Biological clocks and blood clots in space: circadian disruption-induced modulation of thrombosis risk.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- The effect of spaceflight and simulated microgravity exposure on thermoregulation in humans: a systematic review.NPJ microgravity · 2026Article
- From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices.npj aging · 2026Article
- Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials.Annals of intensive care · 2025Article
- Circadian rhythm of heart rate and heart rate variability in pregnancy.npj women's health · 2025Article
- The specificities, influencing factors, and medical implications of bone circadian rhythms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Review
- Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan.NPJ digital medicine · 2024Article
- Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments.International journal of molecular sciences · 2024Article
- Effect of 60 days of head down tilt bed rest on amplitude and phase of rhythms in physiology and sleep in men.NPJ microgravity · 2024Article
- Combined effect of the smartphone addiction and physical activity on the depressive symptoms in secondary school students: a cross sectional study in Shanghai, China.Frontiers in psychiatry · 2024Article
- Effects of exercise on circadian rhythms in humans.Frontiers in pharmacology · 2023Review
- Physical Rehabilitation Programs for Bedridden Patients with Prolonged Immobility: A Scoping Review.International journal of environmental research and public health · 2022Article
- Impact of Circadian Rhythms on the Development and Clinical Management of Genitourinary Cancers.Frontiers in oncology · 2022Review
- Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.Frontiers in neural circuits · 2022Article
- Brains in space: the importance of understanding the impact of long-duration spaceflight on spatial cognition and its neural circuitry.Cognitive processing · 2021Article
- Long-Term Bed Rest Delays the Circadian Phase of Core Body Temperature.Frontiers in physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With NASA's plans for the human exploration of Mars, astronauts will be exposed to mission durations much longer than current spaceflight missions on the International Space Station. These mission durations will increase the risk for circadian misalignment. Exercise has gained increasing interest as a non-pharmacological aid to entrain the circadian system. To assess the potential of exercise as a countermeasure to mitigate the risk for circadian disorders during spaceflight, we investigated the effects of long-term head-down tilt bed rest (HDBR) with and without exercise on the circadian rhythm of core body temperature. Core body temperature was recorded for 24 h using a rectal probe in sixteen healthy men (age: 30.5 ± 7.5 years (mean ± SD)) after 7 days and 49 days of HDBR. Five participants underwent HDBR only (CTR), five participants underwent HDBR and performed resistive exercises (RE), and six participants underwent HDBR and performed resistive exercises superimposed with vibrations (RVE). The exercise was scheduled three times per week. CTR showed a phase delay of 0.69 h. In contrast, both exercise groups were characterized by a phase advance (0.45 h for RE and 0.45 h for RVE; p = 0.026 for interaction between time and group). These findings suggest that resistive exercise (with or without vibration) may also serve as a countermeasure during spaceflight to mitigate circadian misalignments. The results could also be important for increasing awareness about the role of circadian disorders in long-term bedridden patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.