Evidence map›Paper›PMID 33402479›Full record

ArticleIn vivo (Athens, Greece)

Enamel Matrix Derivative in Diffusion Chamber Implanted Subcutaneously in Rat Induces Formation of Fibrous Connective Tissue Containing Abundant Blood Vessels.

Satoshi Yokose, Yuka Kato, Katsutoshi Matsumoto, Perry R Klokkevold, Henry H Takei, Hiroshi Kawazu, Hiroshi Sakagami

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Satoshi YokoseDivision of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan; s-yokose@dent.meikai.ac.jp.
Yuka KatoDivision of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
Katsutoshi MatsumotoDivision of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
Perry R KlokkevoldDivision of Constitutive and Regenerative Sciences, Section of Periodontics, School of Dentistry, University California Los Angeles, Los Angeles, CA, U.S.A.
Henry H TakeiDivision of Constitutive and Regenerative Sciences, Section of Periodontics, School of Dentistry, University California Los Angeles, Los Angeles, CA, U.S.A.
Hiroshi KawazuSection of Continuous Education, School of Dentistry, Meikai University, Saitama, Japan.
Hiroshi SakagamiMeikai University Research Insititute of Odontology (M-RIO), Meikai University School of Dentistry, Saitama, Japan.
Meikai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnamel matrix derivative (EMD) is widely used for regeneration therapy in dental clinical situations, but the mechanism of EMD bioactivity remains obscure. To clarify this mechanism, we focused on the formation of connective tissue and blood vessels. The aim of this study was to confirm whether EMD induces the formation of connective tissue and blood vessels by using the diffusion chamber (DC) technique. MATERIALS AND

methodsIndividual DCs containing EMD (DC-EMD) or propylene glycol alginate (PGA) were implanted subcutaneously in rat dorsum. At 4 weeks after the implantation, histological analysis of DCs was performed using azan staining.

resultsDC-EMD induced the formation of much larger amounts of connective tissue containing abundant blood vessels than did DC-PGA.

conclusionThe results indicated that EMD can induce the formation of both connective tissue and blood vessels. This bioactivity may contribute to the mechanism whereby EMD induces tissue regeneration.

Indexed as

Connective TissueDental Enamel ProteinsAnimalsRatsWound HealingDental Enamel Proteinsblood vesselsconnective tissuediffusion chamberEnamel matrix derivativerat

Identifiers

PMID33402479
PMCPMC7880749
OpenAlexW3120686992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.